EBK GENETICS: FROM GENES TO GENOMES
EBK GENETICS: FROM GENES TO GENOMES
6th Edition
ISBN: 9781260041255
Author: HARTWELL
Publisher: MCGRAW HILL BOOK COMPANY
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Chapter 10, Problem 20P

In the human immune system, so-called B cells can make more than a billion different types of antibody molecules that protect us from infection. However, our genomes have only three genes that encode the polypeptides found in antibodies. What experiments could you perform to determine what kind of combinatorial events occur at the DNA level (V-D-J joining) and RNA level (alternative splicing) for any of these genes?

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Immune System and Immune Response Animation; Author: Medical Sciences Animations;https://www.youtube.com/watch?v=JDdbUBXPKc4;License: Standard YouTube License, CC-BY
Immune response: summary; Author: Dr Bhavsar Biology;https://www.youtube.com/watch?v=ADANgHkX4OY;License: Standard Youtube License