ANATOMY & PHYSIOLOGY: AN INTEGRATIVE AP
3rd Edition
ISBN: 9781264013470
Author: McKinley
Publisher: MCGRAW-HILL LEARNING SOLN.(CC)
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Question
Chapter 10, Problem 20DYB
Summary Introduction
To identify:
The location of both multiunit smooth muscle and single unit smooth muscle and also explain the difference in which each is regulated.
Concept introduction:
Smooth muscle is classified into two groups based on whether the smooth muscle fibers are either stimulated to contract as one unit or independently. Multicellular smooth muscle cells receive stimulation to contract independently whereas contraction in the single unit smooth muscle cells is in a syncytium.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 10 Solutions
ANATOMY & PHYSIOLOGY: AN INTEGRATIVE AP
Ch. 10.1 - Prob. 1LOCh. 10.1 - What are the five major functions of skeletal...Ch. 10.1 - Prob. 2LOCh. 10.1 - Explain the skeletal muscle characteristics of...Ch. 10.2 - Prob. 3LOCh. 10.2 - Prob. 4LOCh. 10.2 - Prob. 5LOCh. 10.2 - Prob. 1WDTCh. 10.2 - Identify the location and function of these...Ch. 10.2 - Prob. 6LO
Ch. 10.2 - Prob. 7LOCh. 10.2 - LEARNING OBJECTIVES
8. Distinguish between thick...Ch. 10.2 - Prob. 9LOCh. 10.2 - Prob. 10LOCh. 10.2 - Prob. 2WDTCh. 10.2 - Draw and label a diagram of a sarcomere.Ch. 10.2 - Prob. 5WDLCh. 10.2 - Prob. 11LOCh. 10.2 - Prob. 12LOCh. 10.2 - Prob. 6WDLCh. 10.2 - Diagram and label the anatomic structures of a...Ch. 10.2 - Prob. 13LOCh. 10.2 - Prob. 8WDLCh. 10.3 - Prob. 14LOCh. 10.3 - What triggers the binding of synaptic vesicles to...Ch. 10.3 - Prob. 15LOCh. 10.3 - What two events are linked in the physiologic...Ch. 10.3 - Prob. 11WDLCh. 10.3 - Prob. 16LOCh. 10.3 - Prob. 3WDTCh. 10.3 - Prob. 12WDLCh. 10.3 - Describe the four processes that repeat in...Ch. 10.3 - What causes the release of the myosin head from...Ch. 10.3 - LEARNING OBJECTIVES
17. Discuss what happens to...Ch. 10.3 - Prob. 18LOCh. 10.3 - How do acetylcholinesterase and Ca2+ pumps...Ch. 10.4 - LEARNING OBJECTIVES
19. Describe how ATP is made...Ch. 10.4 - Prob. 20LOCh. 10.4 - Prob. 4WDTCh. 10.4 - Prob. 16WDLCh. 10.4 - What are the various means for making ATP...Ch. 10.4 - Prob. 21LOCh. 10.4 - Prob. 18WDLCh. 10.5 - Prob. 22LOCh. 10.5 - Prob. 19WDLCh. 10.5 - Prob. 23LOCh. 10.5 - Prob. 20WDLCh. 10.5 - Prob. 24LOCh. 10.5 - Prob. 21WDLCh. 10.6 - LEARNING OBJECTIVE
25. Describe what occurs in a...Ch. 10.6 - Prob. 5WDTCh. 10.6 - What events are occurring in a muscle that produce...Ch. 10.6 - Prob. 26LOCh. 10.6 - What is recruitment? Explain its importance in the...Ch. 10.6 - Prob. 27LOCh. 10.6 - Prob. 24WDLCh. 10.7 - Prob. 28LOCh. 10.7 - What is the function of skeletal muscle tone?Ch. 10.7 - LEARNING OBJECTIVE
29. Distinguish between...Ch. 10.7 - When you flex your biceps brachii while doing...Ch. 10.7 - LEARNING OBJECTIVE
30. Explain the length-tension...Ch. 10.7 - Prob. 27WDLCh. 10.7 - Prob. 31LOCh. 10.7 - How can muscle fatigue result from changes in each...Ch. 10.8 - LEARNING OBJECTIVE
32. Compare and contrast the...Ch. 10.8 - Prob. 29WDLCh. 10.8 - Prob. 33LOCh. 10.8 - Prob. 30WDLCh. 10.9 - Prob. 34LOCh. 10.9 - What are three anatomic or physiologic differences...Ch. 10.10 - Prob. 35LOCh. 10.10 - Prob. 32WDLCh. 10.10 - LEARNING OBJECTIVE
36. Compare the microscopic...Ch. 10.10 - Prob. 33WDLCh. 10.10 - Prob. 34WDLCh. 10.10 - Prob. 37LOCh. 10.10 - What are the steps of smooth muscle contraction?Ch. 10.10 - What unique characteristics of smooth muscle allow...Ch. 10.10 - Prob. 38LOCh. 10.10 - Prob. 37WDLCh. 10.10 - Prob. 38WDLCh. 10.10 - Prob. 39LOCh. 10.10 - LEARNING OBJECTIVES
40. Compare the location and...Ch. 10.10 - Prob. 39WDLCh. 10 - Prob. 1DYBCh. 10 - The physiologic event that takes place at the...Ch. 10 - In a skeletal muscle fiber, Ca2+ is released from...Ch. 10 - The bundle of dense regular connective tissue that...Ch. 10 - In excitation-contraction coupling, the transverse...Ch. 10 - During muscle contraction, the I band a. hides the...Ch. 10 - During a concentric contraction of a muscle fiber,...Ch. 10 - What event causes a troponin-tropomyosin complex...Ch. 10 - In sustained, moderate exercise, skeletal muscle...Ch. 10 - Skeletal muscle and cardiac muscle are similar in...Ch. 10 - Explain the structural relationship between a...Ch. 10 - Prob. 12DYBCh. 10 - Prob. 13DYBCh. 10 - Put the following skeletal muscle contraction...Ch. 10 - Explain the various means of providing ATP for...Ch. 10 - Explain why athletes who excel at short sprints...Ch. 10 - Explain why skeletal muscle generates the most...Ch. 10 - Prob. 18DYBCh. 10 - Describe the response of smooth muscle to...Ch. 10 - Prob. 20DYBCh. 10 - Prob. 1CALCh. 10 - One of the primary reasons that one individual is...Ch. 10 - Prob. 3CALCh. 10 - Rigor mortis occurs following death because a....Ch. 10 - Prob. 5CALCh. 10 - Prob. 1CSLCh. 10 - Describe the effect of the botulinum toxin, which...Ch. 10 - Smooth muscle is within the urinary bladder wall....
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