The possibility of generation of novel life forms from a flask with boiled yeast broth, amino acids and essential inorganic salts , under two conditions: Flask with all the contents exposed to air and not exposed to air. Introduction: Aristotle formulated the doctrine for the Theory of Spontaneous regeneration which suggested that living forms arise from nonliving matter. This theory was challenged by several scientists including Francesco Redi, Louis Pasteur and John Tyndall. Louis Pasteur gave a major breakthrough with an experiment which nullified the theory with his famous swan neck flask. Microorganisms and their spores can be airborne, water borne and soil borne.

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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.

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Chapter 1, Problem 3Q

Summary Introduction

To explain: The possibility of generation of novel life forms from a flask with boiled yeast broth, amino acids and essential inorganic salts , under two conditions: Flask with all the contents exposed to air and not exposed to air.

Introduction:

Aristotle formulated the doctrine for the Theory of Spontaneous regeneration which suggested that living forms arise from nonliving matter. This theory was challenged by several scientists including Francesco Redi, Louis Pasteur and John Tyndall. Louis Pasteur gave a major breakthrough with an experiment which nullified the theory with his famous swan neck flask. Microorganisms and their spores can be airborne, water borne and soil borne.

Summary Introduction

To explain: Redesigning the experiment to eliminate the possibility of contamination.

Introduction:

Aristotle formulated the doctrine for the Theory of Spontaneous regeneration which suggested that living forms arise from nonliving matter. This theory was challenged by several scientists including Francesco Redi, Louis Pasteur and John Tyndall. Louis Pasteur gave a major breakthrough with an experiment which nullified the theory with his famous swan neck flask. Microorganisms and their spores can be airborne, water borne and soil borne.

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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.

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