EBK HUMAN PHYSIOLOGY
15th Edition
ISBN: 9781260163049
Author: Fox
Publisher: MCGRAW HILL BOOK COMPANY
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Chapter 1, Problem 21RA
Why are interactions between the body-fluid compartments essential for sustaining life?
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
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Chapter 1 Solutions
EBK HUMAN PHYSIOLOGY
Ch. 1 - How has the study of physiology aided, and been...Ch. 1 - Describe the steps involved in the scientific...Ch. 1 - Describe the different types of trials a new drug...Ch. 1 - Define homeostasis and describe how this concept...Ch. 1 - Define negative feedback and explain how it....Ch. 1 - Prob. 4CPCh. 1 - Explain how the secretion of a hormone is...Ch. 1 - List the four primary tissues and describe the...Ch. 1 - Compare and contrast the three types of muscle...Ch. 1 - Describe the different types of epithelial...
Ch. 1 - Prob. 7aCPCh. 1 - Describe the different types of connective tissues...Ch. 1 - State the location of each type of primary tissue...Ch. 1 - Describe the functions of nervous, muscle, and...Ch. 1 - Describe the functions of the epidermis and...Ch. 1 - Prob. 9CPCh. 1 - Glands are derived from...Ch. 1 - Cells joined tightly together are characteristic...Ch. 1 - Cells are separated by large extracellular spaces...Ch. 1 - Blood vessels and nerves are usually located...Ch. 1 - Most organs are composed of...Ch. 1 - Sweat is secreted by exocrine glands. This means...Ch. 1 - Which of these statements about homeostasis is...Ch. 1 - In a negative feedback loop, the effector produces...Ch. 1 - A hormone called parathyroid hormone acts to help...Ch. 1 - Which of these consists of dense parallel...Ch. 1 - Prob. 11RACh. 1 - Prob. 12RACh. 1 - Describe the structure of the various epithelial...Ch. 1 - Compare bone, blood, and the dermis of the skin in...Ch. 1 - Describe the role of antagonistic negative...Ch. 1 - Using insulin as an example, explain how the...Ch. 1 - Describe the steps in the development of...Ch. 1 - Why is Claude Bernard considered the father of...Ch. 1 - Prob. 19RACh. 1 - Prob. 20RACh. 1 - Why are interactions between the body-fluid...Ch. 1 - Prob. 22RACh. 1 - Give examples of adult stem cells and explain...Ch. 1 - Prob. 24RACh. 1 - Prob. 25RACh. 1 - Prob. 26RA
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