
Concept explainers
(a1)
To determine: The relation between MRS and ∆G˚ of the binding reaction.
Introduction: Various compounds taste sweet. Some of them sweet more, while some of them sweet lesser. The sweetness is related to their structures and interaction with taste bud receptors. Molar relative sweetness (MRS) is the measure of sweetness of the compound relative to sweetness of sucrose.
(a2)
To determine: Whether the more negative value of ∆G˚ will correspond to a higher or lower MRS.
Introduction: Various compounds taste sweet. Some of them sweet more, while some of them sweet less. The sweetness is related to their structures and taste bud receptors on which the compounds bind. Molar relative sweetness (MRS) is the measure of sweetness of the compound relative to sweetness of sucrose.
(b)
To explain: The uses of predicting the sweetness of molecules by computer model instead of a human or animal-based taste assay.
Introduction: Various compounds taste sweet. Some of them sweet more, while some of them sweet lesser. The sweetness is related to their structures and taste bud receptors. The assay that requires less time to generate valuable result would be convenient and desirable.
(c)
To determine: The AH-B groups in each of the given molecules when the length of a typical single bond is about 0.15 nm
Introduction: Various compounds taste sweet. Some of them sweet more, while some of them sweet lesser. The sweetness is related to their structures and taste bud receptors.
(d)
To determine: The two objections to the statement that molecules containing an AH-B structure will taste sweet are to be determined.
Introduction: Various compounds taste sweet. Some of them sweet more, while some of them sweet lesser. The sweetness is related to their structures and taste bud receptors.
(e)
To determine: The two molecules out of given molecules that can be used to explain the difference in MRS and ∆G˚ and their relation to AH-B model.
Introduction: Various compounds taste sweet. Some of them sweet more, while some of them sweet lesser. The sweetness is related to their structures and taste bud receptors. Molar relative sweetness (MRS) is the measure of sweetness of the compound relative to sweetness of sucrose.
(f)
To determine: The two examples that can be used to argue the AH-B model is unable to explain the observed differences in sweetness.
Introduction: Various compounds taste sweet. Some of them sweet more, while some of them sweet lesser. The sweetness is related to their structures and taste bud receptors. Molar relative sweetness (MRS) is the measure of sweetness of the compound relative to sweetness of sucrose.
(g)
To determine: Whether need to test the model against a different set of molecules from the set it was trained on.
Introduction: Various compounds taste sweet. Some of them sweet more, while some of them sweet lesser. The sweetness is related to their structures and taste bud receptors.
(h)
To determine: The resulting error in MRS values as it has found that the predicted ∆G˚ values for the test set differed from the actual values by, on average, 1.3 kcal/mol.
Introduction: Various compounds taste sweet. Some of them sweet more, while some of them sweet lesser. The sweetness is related to their structures and taste bud receptors. Molar relative sweetness (MRS) is the measure of sweetness of the compound relative to sweetness of sucrose.

Want to see the full answer?
Check out a sample textbook solution
Chapter 1 Solutions
Lehninger Principles of Biochemistry
- 17. Which one of the compounds below is the major organic product obtained from the following series of reactions? CI benzyl alcohol OH PBr3 Mg 1. CO2 SOCl2 ? ether 2. H+, H₂O CI Cl HO OH CI Cl A B C D Earrow_forward14. What is the IUPAC name of this compound? A) 6-hydroxy-4-oxohexanenitrile B) 5-cyano-3-oxo-1-pentanol C) 5-cyano-1-hydroxy-3-pentanone D) 1-cyano-5-hydroxy-3-pentanone E) 5-hydroxy-3-oxopentanenitrile HO. CNarrow_forward13. What is the IUPAC name of this compound? A) 5-hydroxy-3,3-dimethylpentanoic acid B) 3,3-dimethylpentanoic acid C) 3,3-dimethyl-1-oxo-1,5-pentanediol D) 1,5-dihydroxy-3,3-dimethylpentanal E) 4-hydroxy-2,2-dimethylbutanoic acid HO OHarrow_forward
- Help me understand how carbon disulfide leads to toxicity in the brain, using terms like distal axonopathy, neurofilaments, covalent cross-linking, adducts, etc.,...please intuitively explain what is happening and where and the effects of it. For example, I know that CS2 reacts with amide and sulfhydryl groups on proteins, but what proteins exactly and where are they located?arrow_forwardWhat is the standard free energy change (in kJ/mole) of the spontaneous reaction between Oxygen and NADH to form H2O2 and NAD+?arrow_forwardRedox Chemistry: Give standard free energy changes expected for the following reactions:-Succinate -> fumarate (using FAD/FADH2)-Oxaloacetate -> Malate (using NAD/NADH)-NADH --> NAD+ (using FMN/FMNH2)-CoQ --> CoQH2 (using Cytochrome C)arrow_forward
- Give examples of balanced redox reactions that match the following:-Catabolic-Anabolic-Oxidative-Reductivearrow_forwardIf there are 20uM of a GLUT2 transporter on the surface of a cell, each able to move 8 per second, and 50mM glucose outside of the cell, what is the flux into the cell in mM/sec?arrow_forwardA transporter is responsible for antiporting calcium and glucose. The transporter brings glucose into the cell and sends calcium out of the cell. If blood [calcium] = 2.55mM and intracellular [calcium] = 7uM, blood [glucose] = 5.2mM, and intracellular [glucose] = 40uM, what is the free energy of transport? Assume a membrane potential of 62mV (negative inside).arrow_forward
- An ATP-coupled transporter is used to import 1 phosphate from the extracellular environment. Intracellular phosphate exists at 65mM, while it is 2mM outside.Assume a free energy change of ATP hydrolysis of -42.7 kJ/mol. What is the net free energy change of the coupled reaction? Assume a membrane potential of 70mV.arrow_forwardAnother transporter brings 3 chloride ions into the cell. Outside, chloride has a concentration of 107mM, and 4mM inside the cell. Assuming a membrane potential of 62mV (negative inside), what is the free energy of transport of these ions?arrow_forwardFor the Oxaloacetate -> Malate reaction, assume the normal ratio of NAD/NADH, what is the maximum ratio of Malate/Oxaloacetate that will allow reaction progress?arrow_forward
- BiochemistryBiochemistryISBN:9781319114671Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.Publisher:W. H. FreemanLehninger Principles of BiochemistryBiochemistryISBN:9781464126116Author:David L. Nelson, Michael M. CoxPublisher:W. H. FreemanFundamentals of Biochemistry: Life at the Molecul...BiochemistryISBN:9781118918401Author:Donald Voet, Judith G. Voet, Charlotte W. PrattPublisher:WILEY
- BiochemistryBiochemistryISBN:9781305961135Author:Mary K. Campbell, Shawn O. Farrell, Owen M. McDougalPublisher:Cengage LearningBiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage LearningFundamentals of General, Organic, and Biological ...BiochemistryISBN:9780134015187Author:John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. PetersonPublisher:PEARSON





