GENERAL,ORGANIC,+BIO.CHEM.-MINDTAP
7th Edition
ISBN: 9781305866966
Author: STOKER
Publisher: CENGAGE L
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Chapter 1, Problem 1.63EP
Assign each of the following molecular descriptions for a pure substance to the categories (1) must be an element, (2) must be a compound, or (3) could be an element or a compound.
- a. Molecules are triatomic.
- b. Molecules contain only one kind of atom.
- c. Molecules are heteroatomic.
- d. Molecules are both homoatomic and diatomic.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 1 Solutions
GENERAL,ORGANIC,+BIO.CHEM.-MINDTAP
Ch. 1.1 - Prob. 1QQCh. 1.1 - Which of the following is classified as matter? a....Ch. 1.1 - Prob. 3QQCh. 1.2 - Prob. 1QQCh. 1.2 - Prob. 2QQCh. 1.2 - Prob. 3QQCh. 1.3 - Prob. 1QQCh. 1.3 - Prob. 2QQCh. 1.3 - In which of the following pairs of properties are...Ch. 1.4 - Prob. 1QQ
Ch. 1.4 - Prob. 2QQCh. 1.4 - Prob. 3QQCh. 1.5 - Prob. 1QQCh. 1.5 - Prob. 2QQCh. 1.5 - Prob. 3QQCh. 1.5 - Prob. 4QQCh. 1.6 - Prob. 1QQCh. 1.6 - A compound can be separated into its constituent...Ch. 1.6 - Prob. 3QQCh. 1.6 - Prob. 4QQCh. 1.7 - Which of the following statements concerning the...Ch. 1.7 - Prob. 2QQCh. 1.7 - Prob. 3QQCh. 1.7 - Prob. 4QQCh. 1.8 - The correct chemical symbol for the element...Ch. 1.8 - Prob. 2QQCh. 1.8 - Prob. 3QQCh. 1.8 - Prob. 4QQCh. 1.9 - Prob. 1QQCh. 1.9 - Prob. 2QQCh. 1.9 - The molecules present in a compound must be a....Ch. 1.9 - Prob. 4QQCh. 1.10 - Prob. 1QQCh. 1.10 - Which of the following chemical formulas fits the...Ch. 1.10 - Which of the following pairings of chemical...Ch. 1.10 - Prob. 4QQCh. 1.10 - Prob. 5QQCh. 1.10 - Prob. 6QQCh. 1 - What are the two general characteristics that all...Ch. 1 - What are the three aspects of matter that are of...Ch. 1 - Classify each of the following as matter or energy...Ch. 1 - Classify each of the following as matter or energy...Ch. 1 - Prob. 1.5EPCh. 1 - Prob. 1.6EPCh. 1 - Indicate whether each of the following substances...Ch. 1 - Indicate whether each of the following substances...Ch. 1 - Classify each of the following properties of the...Ch. 1 - Classify each of the following properties of the...Ch. 1 - Indicate whether each of the following statements...Ch. 1 - Indicate whether each of the following statements...Ch. 1 - Prob. 1.13EPCh. 1 - Classify each of the following observations about...Ch. 1 - Classify each of the following changes as physical...Ch. 1 - Classify each of the following changes as physical...Ch. 1 - Prob. 1.17EPCh. 1 - Classify each of the following changes as physical...Ch. 1 - Correctly complete each of the following sentences...Ch. 1 - Correctly complete each of the following sentences...Ch. 1 - Classify each of the following as (1) a physical...Ch. 1 - Classify each of the following as (1) a physical...Ch. 1 - Classify each of the following statements as true...Ch. 1 - Classify each of the following statements as true...Ch. 1 - Prob. 1.25EPCh. 1 - Assign each of the following descriptions of...Ch. 1 - Classify each of the following as a heterogeneous...Ch. 1 - Classify each of the following as a heterogeneous...Ch. 1 - From the information given, classify each of the...Ch. 1 - From the information given, classify each of the...Ch. 1 - Prob. 1.31EPCh. 1 - From the information given in the following...Ch. 1 - Indicate whether each of the following statements...Ch. 1 - Indicate whether each of the following statements...Ch. 1 - Consider two boxes with the following contents:...Ch. 1 - Consider two boxes with the following contents:...Ch. 1 - Assign each of the following descriptions of...Ch. 1 - Assign each of the following descriptions of...Ch. 1 - Indicate whether each of the following samples of...Ch. 1 - Indicate whether each of the following samples of...Ch. 1 - Indicate whether each of the following...Ch. 1 - Indicate whether each of the following...Ch. 1 - Indicate whether each of the following statements...Ch. 1 - Indicate whether each of the following statements...Ch. 1 - Prob. 1.45EPCh. 1 - Indicate whether each of the following statements...Ch. 1 - Prob. 1.47EPCh. 1 - Prob. 1.48EPCh. 1 - Give the name of the element denoted by each of...Ch. 1 - Prob. 1.50EPCh. 1 - Prob. 1.51EPCh. 1 - Prob. 1.52EPCh. 1 - Write the chemical symbol for each member of the...Ch. 1 - Write the chemical symbol for each member of the...Ch. 1 - In which of the following sequences of elements do...Ch. 1 - In which of the following sequences of elements do...Ch. 1 - Classify the substances represented by the...Ch. 1 - Classify the substances represented by the...Ch. 1 - Classify the substances represented by the models...Ch. 1 - Classify the substances represented by the models...Ch. 1 - Classify the substances represented by the models...Ch. 1 - Classify the substances represented by the models...Ch. 1 - Assign each of the following molecular...Ch. 1 - Assign each of the following molecular...Ch. 1 - Indicate whether each of the following statements...Ch. 1 - Indicate whether each of the following statements...Ch. 1 - In the following diagrams, the different colored...Ch. 1 - In the following diagrams, different colored...Ch. 1 - Assign each of the following descriptions of...Ch. 1 - Assign each of the following descriptions of...Ch. 1 - In the following diagram, the different colored...Ch. 1 - Using the diagrams given in problem 1-71, select...Ch. 1 - Write chemical formulas for the substances...Ch. 1 - Write chemical formulas for the substances...Ch. 1 - Prob. 1.75EPCh. 1 - Prob. 1.76EPCh. 1 - Prob. 1.77EPCh. 1 - Prob. 1.78EPCh. 1 - Write all possible chemical formulas for a...Ch. 1 - Write all possible chemical formulas for a...Ch. 1 - Write a chemical formula for each of the following...Ch. 1 - Write a chemical formula for each of the following...Ch. 1 - Prob. 1.83EPCh. 1 - Prob. 1.84EPCh. 1 - On the basis of the given information, determine...Ch. 1 - On the basis of the information given, determine...Ch. 1 - Prob. 1.87EPCh. 1 - A mixture contains the following five pure...
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