The apparent contradiction of the fact that more Benzedrine is required than Dexedrine to yield the same physiological response. Introduction: A carbon which has all the four different atoms or group of atoms has a tetrahedral geometry and such carbon molecule is referred as the chiral carbon. The two different forms in which a single chiral center can exist is referred as enantiomers. The narcolepsy and other related disorders are treated by amphetamine enantiomer (Dextroamphetamine). This medication is used because it is a potent central nervous system stimulant. The medications like Benzedrine and Dexedrine are similar in structure, but their physiological effects are different.

Question

Poly-L-leucine in an organic solvent such as dioxane is a helical, whereas poly-L-isoleucine is not. Why do these amino acids with the same number and kinds of atoms have different helix-forming tendencies? L-isoleucine's methyl group sterically interferes with α-helix formation, whereas L-leucine's methyl group does not interfere. L-isoleucine lacks an NH group that can donate a hydrogen bond to stabilize an a helix, whereas L-leucine has an NH group. L-isoleucine contains a hydrogen-bond acceptor in close proximity to the main chain, whereas L-leucine lacks this group. L-isoleucine's ring structure prevents it from assuming the op value to fit into an a helix, whereas L-isoleucine does not have a ring structure.

Answer 1

Question

Chapter 1, Problem 11P

Summary Introduction

To determine: The apparent contradiction of the fact that more Benzedrine is required than Dexedrine to yield the same physiological response.

Introduction:

A carbon which has all the four different atoms or group of atoms has a tetrahedral geometry and such carbon molecule is referred as the chiral carbon. The two different forms in which a single chiral center can exist is referred as enantiomers.

The narcolepsy and other related disorders are treated by amphetamine enantiomer (Dextroamphetamine). This medication is used because it is a potent central nervous system stimulant. The medications like Benzedrine and Dexedrine are similar in structure, but their physiological effects are different.

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