You want to find a drug which inhibits this calcium response pathway in normal cells where it is activated by a signal molecule (red dot). You decide to do mass screening to find that drug. You obtain a large collection of chemical compounds to screen. You make sure that they do not kill the cells and you test them in the following way: you treat the cells with the compounds and then stimulate the cells with the signal molecule (red dot) and analyze the response. Only one compound had an effect you call it drug#1. When the cells are treated with drug#1, and then stimulated with the signal molecule, you find that: 1) cytosolic calcium concentration is low, 2) DAG is not found in membranes, and 3) G-proteins binds GTP normally in drug-treated cells. Give a possible mechanism of action of this drug.
You want to find a drug which inhibits this calcium response pathway in normal cells where it is activated by a signal molecule (red dot). You decide to do mass screening to find that drug. You obtain a large collection of chemical compounds to screen. You make sure that they do not kill the cells and you test them in the following way: you treat the cells with the compounds and then stimulate the cells with the signal molecule (red dot) and analyze the response. Only one compound had an effect you call it drug#1. When the cells are treated with drug#1, and then stimulated with the signal molecule, you find that: 1) cytosolic calcium concentration is low, 2) DAG is not found in membranes, and 3) G-proteins binds GTP normally in drug-treated cells. Give a possible mechanism of action of this drug.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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You want to find a drug which inhibits this calcium response pathway in normal cells where it is activated by a signal molecule (red dot). You decide to do mass screening to find that drug. You obtain a large collection of chemical compounds to screen. You make sure that they do not kill the cells and you test them in the following way: you treat the cells with the compounds and then stimulate the cells with the signal molecule (red dot) and analyze the response. Only one compound had an effect you call it drug#1.
When the cells are treated with drug#1, and then stimulated with the signal molecule, you find that: 1) cytosolic calcium concentration is low, 2) DAG is not found in membranes, and 3) G-proteins binds GTP normally in drug-treated cells.
Give a possible mechanism of action of this drug.
![STUDENT NAME:
signaling
otein coupled receptor (GPCR) signaling pathway:
PI 4,5-bisphosphate
(PI(4,5)P2]
signal molecule
activated GPCR
activated
phospholipase C-B
diacylglycerol
al
rge
n.
GTP
activated
protein
inositol
1,4,5-trisphosphate
(IP)
activated G.
kinase C
Ca 2+
open IP,-gated
protein
Ca-release
channel
lumen of
endoplasmic
reticulum
3) G-proteins binds GTP normally in drug-treated cells.
rug.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fb38f11b4-2041-4b9a-99fb-b8e390e6e98c%2F52ab8918-fc42-4083-907d-eef4323a94a6%2Fwy1ez8k_processed.jpeg&w=3840&q=75)
Transcribed Image Text:STUDENT NAME:
signaling
otein coupled receptor (GPCR) signaling pathway:
PI 4,5-bisphosphate
(PI(4,5)P2]
signal molecule
activated GPCR
activated
phospholipase C-B
diacylglycerol
al
rge
n.
GTP
activated
protein
inositol
1,4,5-trisphosphate
(IP)
activated G.
kinase C
Ca 2+
open IP,-gated
protein
Ca-release
channel
lumen of
endoplasmic
reticulum
3) G-proteins binds GTP normally in drug-treated cells.
rug.
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