You discover a new gene cluster from a strain of the bacterium Streptomyces. The domains of the four-module mixed NRPS/PKS assembly line are shown below, along with relevant starting material: Module 1 Domains 3 4 A, PCP AT, ACP, KS, KR AT, ACP, KS, KR, DH, ER Methyl Malonyl CoA А, РСР, С, Е, MT, ТЕ Val Substrate Editing domains: KR = beta-keto-reductase; DH = dehydratase; ER = enoyl reductase; MT = methyl transferase; E = epimerase Ala Malonyl CoA `S-COA `S-CoA Malonyl CoA Methyl Malonyl CoA Draw the structure of the natural product that would result from the assembly line above if the TE domain functions as a hydrolase. Please only include the stereochemistry for the amino acid side chains.
You discover a new gene cluster from a strain of the bacterium Streptomyces. The domains of the four-module mixed NRPS/PKS assembly line are shown below, along with relevant starting material: Module 1 Domains 3 4 A, PCP AT, ACP, KS, KR AT, ACP, KS, KR, DH, ER Methyl Malonyl CoA А, РСР, С, Е, MT, ТЕ Val Substrate Editing domains: KR = beta-keto-reductase; DH = dehydratase; ER = enoyl reductase; MT = methyl transferase; E = epimerase Ala Malonyl CoA `S-COA `S-CoA Malonyl CoA Methyl Malonyl CoA Draw the structure of the natural product that would result from the assembly line above if the TE domain functions as a hydrolase. Please only include the stereochemistry for the amino acid side chains.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
Related questions
Question
Please answer
![You discover a new gene cluster from a strain of the bacterium Streptomyces. The
domains of the four-module mixed NRPS/PKS assembly line are shown below, along with
relevant starting material:
Module
1
3
4
А, РСР, С, Е,
МТ, ТЕ
Val
Domains
А, РСP | АT, АСР, KS, KR
AT, ACP, KS, KR,
DH, ER
Methyl Malonyl CoA
Malonyl CoA
Substrate
Editing domains: KR = beta-keto-reductase; DH = dehydratase; ER = enoyl reductase;
MT = methyl transferase; E = epimerase
Ala
%3D
S-COA
S-COA
Malonyl CoA
Methyl Malonyl CoA
Draw the structure of the natural product that would result from the assembly line above
if the TE domain functions as a hydrolase. Please only include the stereochemistry for
the amino acid side chains.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F6ac14f2f-6ed0-4a03-a0e6-11c79f78d675%2F235e14a6-fd84-41cb-bc11-91057e06c0ab%2F7au7l8_processed.png&w=3840&q=75)
Transcribed Image Text:You discover a new gene cluster from a strain of the bacterium Streptomyces. The
domains of the four-module mixed NRPS/PKS assembly line are shown below, along with
relevant starting material:
Module
1
3
4
А, РСР, С, Е,
МТ, ТЕ
Val
Domains
А, РСP | АT, АСР, KS, KR
AT, ACP, KS, KR,
DH, ER
Methyl Malonyl CoA
Malonyl CoA
Substrate
Editing domains: KR = beta-keto-reductase; DH = dehydratase; ER = enoyl reductase;
MT = methyl transferase; E = epimerase
Ala
%3D
S-COA
S-COA
Malonyl CoA
Methyl Malonyl CoA
Draw the structure of the natural product that would result from the assembly line above
if the TE domain functions as a hydrolase. Please only include the stereochemistry for
the amino acid side chains.
Expert Solution
![](/static/compass_v2/shared-icons/check-mark.png)
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
This is a popular solution!
Trending now
This is a popular solution!
Step by step
Solved in 3 steps with 1 images
![Blurred answer](/static/compass_v2/solution-images/blurred-answer.jpg)
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Recommended textbooks for you
![Biochemistry](https://www.bartleby.com/isbn_cover_images/9781319114671/9781319114671_smallCoverImage.jpg)
Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman
![Lehninger Principles of Biochemistry](https://www.bartleby.com/isbn_cover_images/9781464126116/9781464126116_smallCoverImage.gif)
Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman
![Fundamentals of Biochemistry: Life at the Molecul…](https://www.bartleby.com/isbn_cover_images/9781118918401/9781118918401_smallCoverImage.gif)
Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY
![Biochemistry](https://www.bartleby.com/isbn_cover_images/9781319114671/9781319114671_smallCoverImage.jpg)
Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman
![Lehninger Principles of Biochemistry](https://www.bartleby.com/isbn_cover_images/9781464126116/9781464126116_smallCoverImage.gif)
Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman
![Fundamentals of Biochemistry: Life at the Molecul…](https://www.bartleby.com/isbn_cover_images/9781118918401/9781118918401_smallCoverImage.gif)
Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY
![Biochemistry](https://www.bartleby.com/isbn_cover_images/9781305961135/9781305961135_smallCoverImage.gif)
Biochemistry
Biochemistry
ISBN:
9781305961135
Author:
Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:
Cengage Learning
![Biochemistry](https://www.bartleby.com/isbn_cover_images/9781305577206/9781305577206_smallCoverImage.gif)
Biochemistry
Biochemistry
ISBN:
9781305577206
Author:
Reginald H. Garrett, Charles M. Grisham
Publisher:
Cengage Learning
![Fundamentals of General, Organic, and Biological …](https://www.bartleby.com/isbn_cover_images/9780134015187/9780134015187_smallCoverImage.gif)
Fundamentals of General, Organic, and Biological …
Biochemistry
ISBN:
9780134015187
Author:
John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:
PEARSON