You are assigned to create new MRNA vaccine. You identified target protein (gene) for vaccine and RNA of that gene is isolated. a) When you create an RNA vaccine, what specific structure/sequence need to be added to the viral RNA that you isolated? Note that mRNA introduced into cells (obviously human cells) as a vaccine needs to be translated efficiently in cells. w b) When you introduced your designed mRNA vaccine to two different cells (Cell A and Cell B), you observed that Cell A produced the target protein (antigen), but Cell B did not produce the target protein well. What could be the reason for this difference? I c) Based on the reason above, how can you overcome that problem?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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You are assigned to create new mRNA vaccine. You identified target protein (gene) for
vaccine and RNA of that gene is isolated.
a) When you create an RNA vaccine, what specific structure/sequence need to be added
to the viral RNA that you isolated? Note that mRNA introduced into cells (obviously
human cells) as a vaccine needs to be translated efficiently in cells.
b) When you introduced your designed mRNA vaccine to two different cells (Cell A and
Cell B), you observed that Cell A produced the target protein (antigen), but Cell B did not
produce the target protein well. What could be the reason for this difference? I
c) Based on the reason above, how can you overcome that problem?
Transcribed Image Text:You are assigned to create new mRNA vaccine. You identified target protein (gene) for vaccine and RNA of that gene is isolated. a) When you create an RNA vaccine, what specific structure/sequence need to be added to the viral RNA that you isolated? Note that mRNA introduced into cells (obviously human cells) as a vaccine needs to be translated efficiently in cells. b) When you introduced your designed mRNA vaccine to two different cells (Cell A and Cell B), you observed that Cell A produced the target protein (antigen), but Cell B did not produce the target protein well. What could be the reason for this difference? I c) Based on the reason above, how can you overcome that problem?
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