Write a balanced equation for the synthesis of sn-1-stearoyl-2-oleylglycerophosphorylserine, starting with glycerol, the fatty acidsinvolved, and serine.

Answered: Write a balanced equation for the…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Question

Write a balanced equation for the synthesis of sn-1-stearoyl-2-
oleylglycerophosphorylserine, starting with glycerol, the fatty acids
involved, and serine.

Expert Solution

Introduction

Phospholipids are lipids containing two fatty acids, glycerol, and a head group (serine, choline, etc.). The synthesis occurs on the cytosolic side of the endoplasmic reticulum. Phosphatidylserine is usually synthesized from phosphatidylcholine in a calcium dependant way.

Explanation

sn-1-stearoyl-2-oleylglycerophosphorylserine contains two fatty acids:

stearic acid
oleic acid

It also contains serine head group and glycerol

Fatty acids are attached as follows:

$fatty acyl - {CoA}^{1} + glycerol + 2 NADPH + 2 H + + Fatty {alcohol}^{2} + fatty acyl - {CoA}^{3} + ATP \to 1, 2 - diacylglycerol$

Diacylglyrecol is then converted to phospholipid:

$diacylglycerol + ATP + CTP + Serine \to phosphatidylserine$

Therefore, sn-1-stearoyl-2-oleylglycerophosphorylserine is synthesized as:

$fatty acyl - CoA + glecerol + 2 NADPH + 2 H^{+} + Stearoyl alcohol + oleoyl - CoA + ATP + CTP + serine \to sn - 1 - stearoyl - 2 - oleylglycerophosphorylserine + CDP + ADP + 2 NADP$