Would the base pair Guanosine and Cytosine be more or less stable at pH 10

Biochemistry
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ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
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Would the base pair Guanosine and Cytosine be more or less stable at pH 10 than at pH 7?

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The stability of a base pair like Guanosine (G) and Cytosine (C) can be influenced by pH, but in the case of G-C base pairing, it's important to note that these base pairs are generally stable over a wide pH range.


G-C base pairs are connected by three hydrogen bonds, making them more stable than A-T base pairs, which are connected by only two hydrogen bonds. These three hydrogen bonds provide extra stability to the G-C base pair, making it less likely to denature or break apart.

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