With muscular dystrophy, the membrane of muscle cells is destroyed. Given how muscle cells contract, which of the following would fail to happen? O Reuptake of acetylcholine by the muscle cells Reuptake of acetylcholine by lower motor neurons OAction potential conduction on muscle cells () Action potential conduction on the lower motor neurons
Muscular dystrophy disease is comprised of thirty different genetic disorders causing progressive degeneration of skeletal muscles. The primary cause for these disorders is the mutations of genes that encode extracellular matrix proteins, cytoplasmic enzymes, nuclear matrix proteins, and transmembrane and membrane-associated proteins.
The genetic mutation of genes results in instability of sarcolemma, Abnormal calcium homeostasis, fiber necrosis, inflammatory response, oxidative stress, breakdown of the extracellular matrix, and eventually fibrosis and muscle wasting and degeneration resulting in walking inability, respiratory and cardiac failures, and death.
Most severe forms of muscular dystrophy (Duchenne muscular dystrophy) due to mutations in the dystrophin-glycoprotein complex components in the sarcolemma lead to membrane instability. Dystrophin, the membrane protein, provides mechanical stability to muscle fiber by linking actin in the cytoskeleton to dystroglycan in the sarcolemma. It also regulates the calcium level in the cytoplasm of muscle cells.
The deficiency of dystrophin disrupts sarcolemma and failure of maintenance of resting membrane potential. This membrane instability leads to failure in the generation and conduction of action potential in muscle fibers.
Therefore, option (3) is correct
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