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With given structures of acetophenone, nicotine, and salicylic acid, fill out the following table with appropriate major species at each pH.

With given structures of acetophenone, nicotine, and salicylic acid, fill out the following table with appropriate major species at each pH.

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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LC analysis are sometime performed using buffers as mobile phase to control the pH. The following table lists the retention factors (k) for three analytes separated on a C8 non- polar column. The mobile phase was a citrate buffer: methanol mixture adjusted to given pHs with NH3. a. With given structures of acetophenone, nicotine, and salicylic acid, fill out the following table with appropriate major species at each pH. Structure Acetophenone (no pka) Nicotine (pka1 = 3.15, pka2 = 7.85) Salicylic acid (pka1 = 2.97, pka2 = 13.60) b. CH3 CH3 OH OH pH 2 Analyte Acetophenone Nicotine Salicylic Acid pH 5 pH 2 8.5 0.0 6.0 pH 5 8.5 0.2 1.1 pH 8 pH 8 8.5 6.1 1.1 Based on your structures above, provide explanations on why some of the observed retention factors change with pH of the mobile phase.
Transcribed Image Text:LC analysis are sometime performed using buffers as mobile phase to control the pH. The following table lists the retention factors (k) for three analytes separated on a C8 non- polar column. The mobile phase was a citrate buffer: methanol mixture adjusted to given pHs with NH3. a. With given structures of acetophenone, nicotine, and salicylic acid, fill out the following table with appropriate major species at each pH. Structure Acetophenone (no pka) Nicotine (pka1 = 3.15, pka2 = 7.85) Salicylic acid (pka1 = 2.97, pka2 = 13.60) b. CH3 CH3 OH OH pH 2 Analyte Acetophenone Nicotine Salicylic Acid pH 5 pH 2 8.5 0.0 6.0 pH 5 8.5 0.2 1.1 pH 8 pH 8 8.5 6.1 1.1 Based on your structures above, provide explanations on why some of the observed retention factors change with pH of the mobile phase.
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