Prostaglandins are a class of eicosanoids, fatty acid derivatives with a variety of extremely potent actions on vertebrate tissues. They are responsible for producing fever and inflammation and its associated pain. Prostaglandins are derived from the 20- carbon fatty acid arachidonic acid in a reaction catalyzed by the enzyme prostaglandin endoperoxide synthase. This enzyme, a cyclooxygenase, uses oxygen to convert arachidonic acid to PGG2, the immediate precursor of many different prostaglandins. Rate of formation of PGG2 with 10 mg/ml Arachidonic acid (mM) Rate of formation of PGG2 (mM/min) 0.350 12.3 0.420 13.9 0.630 17.5 1.05 22.2 2.45 28.8 ibuprofen (mM/min) 7.71 8.88 11.9 16.3 24.0 The kinetic data given in the table are for the reaction catalyzed by a mutant of prostaglandin endoperoxide synthase. Focusing here on the first two columns, determine the Vmax and Km of the enzyme. Vmax= Km = mM/min mM

Prostaglandins are a class of eicosanoids, fatty acid derivatives with a variety of extremely potent actions on vertebrate tissues. They are responsible for producing fever and inflammation and its associated pain. Prostaglandins are derived from the 20- carbon fatty acid arachidonic acid in a reaction catalyzed by the enzyme prostaglandin endoperoxide synthase. This enzyme, a cyclooxygenase, uses oxygen to convert arachidonic acid to PGG2, the immediate precursor of many different prostaglandins. Rate of formation of PGG2 with 10 mg/ml Arachidonic acid (mM) Rate of formation of PGG2 (mM/min) 0.350 12.3 0.420 13.9 0.630 17.5 1.05 22.2 2.45 28.8 ibuprofen (mM/min) 7.71 8.88 11.9 16.3 24.0 The kinetic data given in the table are for the reaction catalyzed by a mutant of prostaglandin endoperoxide synthase. Focusing here on the first two columns, determine the Vmax and Km of the enzyme. Vmax= Km = mM/min mM

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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W AutoSave Off 周り File Home Insert Draw Assignment 3-1 Saved to this PC ✓ Design Layout References Mailings Review A A Aa Times New Roman ✓ 12 ✓ Paste BIU ab x² A ✓ く Clipboard Гу Page 5 of 10 1 76°F Clear 254 words ㄈㄨˋ Font Search Christiana Taylor CT Comments Editing ✓ Share View Help Find P ✓ ✓ = = ↓¶ Normal No Spacing Heading Heading 2 ГУ Paragraph ☑ Styles 3. Determine and draw the structure corresponding to the spectral information provided below. As you make this determination, complete the table below. Explain what clues you used to determine the structure. S C5H1002 Signal б ABC -4.3 -2.0 с -1.3 PPM Integration Multiplicity m (multiplet/septet) S d 叹 Text Predictions: On Accessibility: Investigate 2 19 Q Search W ✓ Replace Select ▾ Dictate Editor Add-ins Editing Voice Editor Add-ins > | + 88% Focus 8:01 PM 4/2/2024
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MasteringChemistry .edu/webapps/assessment/take/launch.jsp?course_assessment_id%3_1575667_1&course_id%3_592130_1&content_id%3D_39106439 18 Up pe Maps M Gmail YouTube O Maps * Question Completion Status: QUESTION 4 A student takes 92 ml of a 0.0245 molar KOH solution and dilutes it to a final volume of 4,314.5. What is the pH of that resultant dilute solution? (report pH to two decimal places and include NO units in your answer) QUESTION 5 A student is told by their chemistry professor that he thinks he remembers that the ion product constant for water (Kw) has a value of 1.51x10-14 provided by their chemistry professor from his questionable memory, what is the calculated pH of water at 40 °C ? (Enter your number with 2 decimal places and do NOT include "pH" as a unit in your answer.) when water has the same temperature as that of a human running a hot fever of 40 °C. Based only on this information QUESTION 6 Given the information for equilibria (1) and (2) below, find the equilibrium…
6. Use the following data to calculate the molar mass of naturally occurring silicon: Isotope Isotopic Molar Mass Abundance 28Si 27.97693 g/mol 92.23% 29Si 28.97649 g/mol 4.67% 30Si 29.97376 g/mol 3.10%