Why is it significant that toll-like receptors (TLRs) are found on both the plasma membrane and internal cell membranes?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Why is it significant that toll-like receptors (TLRs) are found on both the plasma membrane and internal cell membranes? 

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 TLRs recognize pathogens and generates an immediate defence response.
 Induce cytokines which destroy or limit invading pathogens.
- Activation of APCs & expression of MHC and co-stimulatory molecules like CD40, CD89, CD86 and CD70.
 Activation and differentiation of naive T cells into Th1, Th2, Th3 and Th17 cells or T-regs, facilitating cell mediated immune responses.

Induce genes involved in immune responses and inflammation.
Act as a bridge between Innate and Adaptive immunity by mediating dendritic cell maturation and activation of pathogen-specific T lymphocytes.

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