Which pairs of amino acid side chains might you expect to find in a salt bridge in aprotein at pH 7.0?A) Serine and GlutamateB) Arginine and PhenylalanineC) Histidine and lysineD) Aspartate and HistidineE) Aspartate and Arginine

Answered: Which pairs of amino acid side chains…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Question

Which pairs of amino acid side chains might you expect to find in a salt bridge in a
protein at pH 7.0?
A) Serine and Glutamate
B) Arginine and Phenylalanine
C) Histidine and lysine
D) Aspartate and Histidine
E) Aspartate and Arginine

Expert Solution

Step 1: Salt bridge between amino acids

Amino acids are the monomer units that adjoin via peptide linkages to form proteins. There are 20 naturally occurring amino acids, and each amino acid possesses one amino-terminal (-NH_3⁺) and a carboxyl-terminal (-COO^-). The peptide bond is formed between two consecutive amino acids the carboxyl end of the first amino acid and the amino terminus of the other amino acid.

The formation of electrostatic interactions between the side chain of the acidic carboxyl group of one amino acid and the basic amino group of another amino acid is termed a salt bridge.