Which of the following is false when the genes of the Lac operon are being tran- scribed in high amounts: A) RNA polymerase is bound to the promoter B) The repressor is bound to the operator C) Allolactose is bound to the repressor D) Cyclic AMP is bound to CAP.

Human Anatomy & Physiology (11th Edition)
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**Question:**

Which of the following is false when the genes of the Lac operon are being transcribed in high amounts:

A) RNA polymerase is bound to the promoter  
B) The repressor is bound to the operator  
C) Allolactose is bound to the repressor  
D) Cyclic AMP is bound to CAP  

**Explanation:**

The Lac operon is a segment of DNA found in E. coli and other bacteria that allows for the metabolism of lactose when glucose is not available. When the operon is active, the following occurs:

- **RNA polymerase** binds to the promoter, initiating transcription.
- **Allolactose** binds to the repressor, preventing it from binding to the operator, hence allowing transcription.
- **Cyclic AMP** binds to the catabolite activator protein (CAP), enhancing transcription in the absence of glucose.

Therefore, option B is false when the operon is highly transcribed, as the repressor should not be bound to the operator; instead, it is inactivated by allolactose.
Transcribed Image Text:**Question:** Which of the following is false when the genes of the Lac operon are being transcribed in high amounts: A) RNA polymerase is bound to the promoter B) The repressor is bound to the operator C) Allolactose is bound to the repressor D) Cyclic AMP is bound to CAP **Explanation:** The Lac operon is a segment of DNA found in E. coli and other bacteria that allows for the metabolism of lactose when glucose is not available. When the operon is active, the following occurs: - **RNA polymerase** binds to the promoter, initiating transcription. - **Allolactose** binds to the repressor, preventing it from binding to the operator, hence allowing transcription. - **Cyclic AMP** binds to the catabolite activator protein (CAP), enhancing transcription in the absence of glucose. Therefore, option B is false when the operon is highly transcribed, as the repressor should not be bound to the operator; instead, it is inactivated by allolactose.
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