Which of the following centers have R chirality? Select all that apply. A.A О в. в Dc.c D.D. DE.E OF.F B E F) None of the above

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**Chirality Problem - Educational Exercise**

**Question:**
Which of the following centers have **R** chirality? Select all that apply.

**Diagram Explanation:**

The diagram presented depicts a molecular structure with several chiral centers labeled A, B, C, D, and E. Each label corresponds to a carbon atom that may potentially be chiral, with its bonds indicated to understand the spatial arrangement:

- **A** appears as a central carbon bonded to different groups, potentially chiral.
- **B** is connected to a carbonyl group (C=O) and potentially chiral.
- **C** is connected to a chlorine (Cl) and other groups that can influence chirality.
- **D** and **E** are additional labeled centers in the molecular structure, located further along the carbon chain.

**Answer Choices:**
- A. A
- B. B
- C. C
- D. D
- E. E
- F. None of the above

To determine which centers have **R** chirality, it is essential to assign priorities to the substituents on each chiral center based on their atomic numbers and use the Cahn-Ingold-Prelog priority rules. Then, the molecule should be oriented so that the lowest priority group is directed away from the viewer. If the sequence from highest to lowest priority goes clockwise, the configuration is **R**. 

**Note:** This transcribed content helps students understand chirality by providing a clear problem statement and detailed explanation of the molecular diagram. Students are encouraged to apply the Cahn-Ingold-Prelog priority rules to determine the chirality of each center.
Transcribed Image Text:**Chirality Problem - Educational Exercise** **Question:** Which of the following centers have **R** chirality? Select all that apply. **Diagram Explanation:** The diagram presented depicts a molecular structure with several chiral centers labeled A, B, C, D, and E. Each label corresponds to a carbon atom that may potentially be chiral, with its bonds indicated to understand the spatial arrangement: - **A** appears as a central carbon bonded to different groups, potentially chiral. - **B** is connected to a carbonyl group (C=O) and potentially chiral. - **C** is connected to a chlorine (Cl) and other groups that can influence chirality. - **D** and **E** are additional labeled centers in the molecular structure, located further along the carbon chain. **Answer Choices:** - A. A - B. B - C. C - D. D - E. E - F. None of the above To determine which centers have **R** chirality, it is essential to assign priorities to the substituents on each chiral center based on their atomic numbers and use the Cahn-Ingold-Prelog priority rules. Then, the molecule should be oriented so that the lowest priority group is directed away from the viewer. If the sequence from highest to lowest priority goes clockwise, the configuration is **R**. **Note:** This transcribed content helps students understand chirality by providing a clear problem statement and detailed explanation of the molecular diagram. Students are encouraged to apply the Cahn-Ingold-Prelog priority rules to determine the chirality of each center.
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