Answered: Which is most negative at a pH of 7…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Question

Which is most negative at a pH of 7 Tyr-Lys-Met Gly-Pro-Ara Asp-Trp-tvr V Asp-His-Glu Leu-Val-Phe His-Ala-His

Expert Solution

Recall that:

Amino acid sequences are written with N-terminal amino acid on the left and C-terminal amino acid on the right.
The peptide bond is formed between the carboxyl group of N-terminal amino acids and the amino group of C-terminal amino acids.
The charge on the amino acid residue will depend on the charge of the ionisable group because charges on alpha-amino/carboxyl groups are neutralised due to the formation of a peptide bond.
Terminal amino/carboxyl groups are ionisable.

pKa is the pH at which a weak acid is 50% dissociated. Changes in pH affect the ionisation of the ionising group.

When pH is less than the pKa of an ionising group, the group remains protonated.
When pH is equal to the pKa of an ionising group, 50% of the ionizing group remains protonated.
When pH is greater than the pKa of an ionising group, the group is deprotonated.

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