Which folate structure (from the list below) (a) Is the substrate for the enzyme that is inhibited by methotrexate and trimethoprim? (b) Has the most highly oxidized one-carbon substituent? (c) Is used in the conversion of serine to glycine? (d) Transfers its one-carbon substituent to a B12 coenzyme? What amino acid is synthesized as the end result of this reaction? (e) Is the coenzyme for the thymidylate synthase reaction? (f) Is not known to exist in nature? (g) Is used in purine nucleotide synthesis? HC=0 10 CH,-N- CH2 HN- N- CH2 CH, N' N- N· N. A B CH, CH, HN- HN- 1. .N. N- H CH2 N. CH, CH, N- H. D E F IZ ZI U C-NG
Which folate structure (from the list below) (a) Is the substrate for the enzyme that is inhibited by methotrexate and trimethoprim? (b) Has the most highly oxidized one-carbon substituent? (c) Is used in the conversion of serine to glycine? (d) Transfers its one-carbon substituent to a B12 coenzyme? What amino acid is synthesized as the end result of this reaction? (e) Is the coenzyme for the thymidylate synthase reaction? (f) Is not known to exist in nature? (g) Is used in purine nucleotide synthesis? HC=0 10 CH,-N- CH2 HN- N- CH2 CH, N' N- N· N. A B CH, CH, HN- HN- 1. .N. N- H CH2 N. CH, CH, N- H. D E F IZ ZI U C-NG
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Transcribed Image Text:Which folate structure (from the list below)
(a) Is the substrate for the enzyme that is inhibited by methotrexate and
trimethoprim?
(b) Has the most highly oxidized one-carbon substituent?
(c) Is used in the conversion of serine to glycine?
(d) Transfers its one-carbon substituent to a B12 coenzyme? What amino
acid is synthesized as the end result of this reaction?
(e) Is the coenzyme for the thymidylate synthase reaction?
(f) Is not known to exist in nature?
(g) Is used in purine nucleotide synthesis?
HC=0
10
CH,-N-
CH2
HN-
N-
CH2
CH,
N'
N-
N·
N.
A
B
CH,
CH, HN-
HN-
1.
.N.
N-
H
CH2
N.
CH,
CH,
N-
H.
D
E
F
IZ
ZI U
C-NG
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