When inactive, they exist in complex with heat shock proteins (Hsps) in the cytoplasm Upon activation, they translocate to the nucleus and directly bind DNA as a transcription factor They contain a DNA binding, a dimerization and an activation domain They are always bound to DNA, but dependent on the presence of their ligand exist in complex with either a corepressor or coactivator

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Vitamin D, thyroid hormone and prostaglandins are all steroid hormones that bind to type II receptors.
Which of the following statements are correct about the mechanism of action of type II steroid
hormone receptors?
O When inactive, they exist in complex with heat shock proteins (Hsps) in the cytoplasm
O Upon activation, they translocate to the nucleus and directly bind DNA as a transcription factor
They contain a DNA binding, a dimerization and an activation domain
They are always bound to DNA, but dependent on the presence of their ligand exist in complex with either a
corepressor or coactivator
Transcribed Image Text:Vitamin D, thyroid hormone and prostaglandins are all steroid hormones that bind to type II receptors. Which of the following statements are correct about the mechanism of action of type II steroid hormone receptors? O When inactive, they exist in complex with heat shock proteins (Hsps) in the cytoplasm O Upon activation, they translocate to the nucleus and directly bind DNA as a transcription factor They contain a DNA binding, a dimerization and an activation domain They are always bound to DNA, but dependent on the presence of their ligand exist in complex with either a corepressor or coactivator
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