What would be the best choices for the missing reagents 1 and 3 in this synthesis?1. PPh332. n-BuLi• Draw the missing reagents in the drawing area below. You can draw them in any arrangement you like.• Do not draw the missing reagent 2. If you draw 1 correctly, we'll know what it is.• Note: if one of your reagents needs to contain a halogen, use bromine.Click and drag to start drawing a structure.

Step 2: Reagent 2 (Formation of the Ylide)n-BuLi (n-butyllithium) is a sturdy base that is used to…

Answered: What would be the best choices for the…

Organic Chemistry: A Guided Inquiry

2nd Edition

ISBN:9780618974122

Author:Andrei Straumanis

Publisher:Andrei Straumanis

Chapter16: Synthesis Workshop 1

Section: Chapter Questions

Problem 8CTQ

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Draw an alkyl bromide that would produce ONLY the following alkene in an E2 elimination. Ignore any inorganic byproducts.
Choose the correct reagent(s) to perform the following transformation. 1. Choose the correct Reagent(s) for I [Select] A. H3O+ B. MCPBA C. RCOOH [Select] ct Reagent(s) for II To preview the image click here OH "Me ||
Choose the correct reagent (s) to perform the following transformation. Reagents for I [Select] Reagents for II [Select] To preview the image click here A. NaNH2 B. NaOEt C. NaOH A. B. H C. 1. OH 2. H3O+ 2. H3O+ HO
Draw the major organic product(s) of the following reaction. Br + NaSCH3 acetonitrile • You do not have to consider stereochemistry. • If no reaction occurs, draw the organic starting material. • When SN1 & E1 pathways compete, show both the substitution and the elimination products. Separate multiple products using the + sign from the drop-down menu. • Do not include counter-ions, e.g., Na*, I', in your answer. [ ] در
Associate the reaction mechanism with the indicated characteristics of the base or nucleophile. Assume that the electrophile bears a good enough leaving group. E2 1. Species is a strong nucleophile but a weak base Could be SN1 or E1, depending on the electrophile's structure 2. Species is a weak nucleophile but a strong base 3. Species is a strong nucleophile and a strong base SN2 Could be SN2 or E2, 4. Species is a weak nucleophile and a depending on the electrophile's structure weak base >
2. Explain why the following Williamson ether synthesis will not work. 1) NaH 2) Br- OH X Propose an alternative synthesis for the desired target molecule by filling in the starting material and the reagent or molecule needed for step 2 in the reaction conditions in the boxes below. 1) NaH 2)
5. a) When compound 5 is treated with methanol it forms a carbocation. Draw the carbocation that would be formed and the best resonance structure of the compound. CH3 5 CH3OH Br b) Below are different conditions that can be used for an SN1 mechanism. In each pair circle the molecule that would provide a faster SN1. If they are equal rates, circle both. a) electrophile b) solvent c) Nucleophile CH3OH CH3OH CH3ONa
True or False 1: The rate of SN2 reactions depends only on the concentration of nucleophile. 2: Dimethyl sulfoxide (DMSO) is a protic solvent that dramatically increase the rate of SN2 reaction. 3: Methanethiolate ( -SCH3) is a good leaving group as well as a good nucleophile. 4: SN2 reaction goes faster when a neutral nucleophile is used. 5: Stereochemical inversion occurs in the SN2 reaction product due to frontside displacement.
Please answer both
10. The methoxy group in anisole, below at left, is a donating group. Draw its resonance structures (fill in à bonds and charges) to show which ring carbons are made more nucleophilic (that is, electron-rich) by the donating group. H3C-Ö: H3C H3C H3C- 11. Draw the first nitration product when acetophenone (above) is treated with nitric acid and sulfuric acid. Then, do the same with anisole (also above). Which reaction is faster?
2
3. Draw all products for the following reactions. For your products, write whether the nucleophile added to the Re face or Si face of the starting material. a. HO b. 1) LIAIH 2) H™ 1) CH3CH2Li 2) H+ c) Determine whether the nucleophile added to the Re face or Si face of benzaldehyde.

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