What value is appropriate to report if the study design was cohort study? A. Chi square = 465.4 B. OR = 83.24 C. p-value < 0.001 D. RR = 16.65

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39. What value is appropriate to report if the study design was cohort study?
A. Chi square = 465.4
B. OR = 83.24
C. p-value < 0.001
D. RR = 16.65
40. What value is appropriate to report if the study design was case-control study?
A. Chi square = 465.4
B. OR = 83.24
C. p-value < 0.001
D. RR = 16.65
41. What measure of association was utilized in the analysis?
A. Chi square test
B. correlation test
C. one-way ANOVA
D. t-test for paired groups
42. Based on the analysis, will maternal age affect the occurrence of Down syndrome?
A. Cannot be known
B. Maybe
C. No
D. Yes 

Single Table Analysis
Down syndrome
>35
417
81%
98 515
19% 100%
23.8%
313 329
95.1%100%
96.3%
16
Age of mother at conception34 and below
4.9%
3.7%
433
51.3%
100%
76.2%
411 844
48.7%100%
100%
Chi Square and Exact Measures of Association
Test
Value p-value(1-tail) p-value(2-tail)
Uncorrected chi square
Yates corrected chỉ square
Mantel-Haenszel chi square
Fisher exact
Mid-P exact
c0.0000001
<0.0000001
465.4
<0.0000001
<0.0000001
462.4
464.9
<0.0000001
<0.0000001
<0.0000001
<0.0000001
<0.0000001
<0.0000001
All expected values (row total"column total grand total) are >=s
OK to use chi square.
Risk-Based* Estimates and 95% Confidence Intervals
(Not valid for Case-Control studies)
Point Estimates
Confidence Limits
Туре
Value Lower, Upper
Туре
Risk in Exposed
Risk in Unexposed
Overall Risk
Risk Ratio
Risk Difference
Etiologic fraction in pop.(EFp) 90.52% 86.12, 94.92
Etiologic fraction in exposed(EFe)93.99%
80.97% 77.35, 84.13 Taylor series
2.959, 7.809 Taylor series
47.93, 54.66 Taylor series
Taylor series
Taylor series
4.863%
51.3%
16.65
76.11%
10.31, 26.9"
72, 80.22°
90.3, 96.28
Odds-Based Estimates and Confidence Limits
Point Estimates
Confidence Limits
Type
Value
Lower, Upper
Type
Mid-P
Exact
Fisher
Exact
Taylor
CMLE Odds Ratio"
82.57
48.71, 147.2
47.34, 153.3
Odds Ratio
83.24
48.1, 144
series
fraction in pop (EFpOR)
Eiologic fraction in exposed(EFe OR)
95.15%
92.8, 97.5
97.92, 99.31
98.8%
*Conditional maximum likelihood estimate of Odds Ratio
(Pjindicates a one-tail P-value for Protective or negative association; otherwise one-tailed exact P-values are for a positive association.
Martin D. Austin, H (1991) An efficient program for computing conditional maximum likelihood estimates and exact confidence limits for a common odds
ratio. Epidemiology 2, 359-362.
** 95% confidence limits testing exclusion of 0 or 1, as indicated
P-values <0.05 and confidence limits excluding null values (0,1, or (a) are highlighted.
LookFirst items: Editor's choice of items to examine first.
Transcribed Image Text:Single Table Analysis Down syndrome >35 417 81% 98 515 19% 100% 23.8% 313 329 95.1%100% 96.3% 16 Age of mother at conception34 and below 4.9% 3.7% 433 51.3% 100% 76.2% 411 844 48.7%100% 100% Chi Square and Exact Measures of Association Test Value p-value(1-tail) p-value(2-tail) Uncorrected chi square Yates corrected chỉ square Mantel-Haenszel chi square Fisher exact Mid-P exact c0.0000001 <0.0000001 465.4 <0.0000001 <0.0000001 462.4 464.9 <0.0000001 <0.0000001 <0.0000001 <0.0000001 <0.0000001 <0.0000001 All expected values (row total"column total grand total) are >=s OK to use chi square. Risk-Based* Estimates and 95% Confidence Intervals (Not valid for Case-Control studies) Point Estimates Confidence Limits Туре Value Lower, Upper Туре Risk in Exposed Risk in Unexposed Overall Risk Risk Ratio Risk Difference Etiologic fraction in pop.(EFp) 90.52% 86.12, 94.92 Etiologic fraction in exposed(EFe)93.99% 80.97% 77.35, 84.13 Taylor series 2.959, 7.809 Taylor series 47.93, 54.66 Taylor series Taylor series Taylor series 4.863% 51.3% 16.65 76.11% 10.31, 26.9" 72, 80.22° 90.3, 96.28 Odds-Based Estimates and Confidence Limits Point Estimates Confidence Limits Type Value Lower, Upper Type Mid-P Exact Fisher Exact Taylor CMLE Odds Ratio" 82.57 48.71, 147.2 47.34, 153.3 Odds Ratio 83.24 48.1, 144 series fraction in pop (EFpOR) Eiologic fraction in exposed(EFe OR) 95.15% 92.8, 97.5 97.92, 99.31 98.8% *Conditional maximum likelihood estimate of Odds Ratio (Pjindicates a one-tail P-value for Protective or negative association; otherwise one-tailed exact P-values are for a positive association. Martin D. Austin, H (1991) An efficient program for computing conditional maximum likelihood estimates and exact confidence limits for a common odds ratio. Epidemiology 2, 359-362. ** 95% confidence limits testing exclusion of 0 or 1, as indicated P-values <0.05 and confidence limits excluding null values (0,1, or (a) are highlighted. LookFirst items: Editor's choice of items to examine first.
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