What type of reaction is occuring in step 3? (halogenation, hydrohalogenation, reduction, keto–enol tautomerism, dehydrohalogenation, acid-catalyzed hydration, base-catalyzed hydration) 2. Which reagent is necessary for step 3? (Br2, HBr, H2/Pt, NaNH2, H20/H2SO4/HgSO4)
Analyzing Infrared Spectra
The electromagnetic radiation or frequency is classified into radio-waves, micro-waves, infrared, visible, ultraviolet, X-rays and gamma rays. The infrared spectra emission refers to the portion between the visible and the microwave areas of electromagnetic spectrum. This spectral area is usually divided into three parts, near infrared (14,290 – 4000 cm-1), mid infrared (4000 – 400 cm-1), and far infrared (700 – 200 cm-1), respectively. The number set is the number of the wave (cm-1).
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IR Spectroscopy
Infrared (IR) or vibrational spectroscopy is a method used for analyzing the particle's vibratory transformations. This is one of the very popular spectroscopic approaches employed by inorganic as well as organic laboratories because it is helpful in evaluating and distinguishing the frameworks of the molecules. The infra-red spectroscopy process or procedure is carried out using a tool called an infrared spectrometer to obtain an infrared spectral (or spectrophotometer).
1. What type of reaction is occuring in step 3? (halogenation, hydrohalogenation, reduction, keto–enol tautomerism, dehydrohalogenation, acid-catalyzed hydration, base-catalyzed hydration)
2. Which reagent is necessary for step 3? (Br2, HBr, H2/Pt, NaNH2, H20/H2SO4/HgSO4)
![**Synthesis of Rimantadine from Adamantane**
*Rimantadine was among the first antiviral drugs to be licensed in the United States to use against the influenza A virus and to treat established illnesses. It is synthesized from adamantane by the following sequence:*
1. **Adamantane** is reacted with bromine (Br2) to produce **1-bromoadamantane**. This is shown as:
- **Adamantane** + Br2 → **1-bromoadamantane** (Step 1)
2. **1-bromoadamantane** is then reacted with **AlBr3** (aluminum bromide) in the presence of **CH2=CHBr** to yield a compound with a newly formed carbon-bromine bond. This is:
- **1-Bromoadamantane** + AlBr3 + CH2=CHBr → Intermediate (Step 2)
3. The intermediate undergoes further transformation to replace the newly added bromine atom, forming a carbon-carbon triple bond product.
4. The intermediate product is then converted to a carbonyl compound.
5. Finally, the carbonyl compound is converted into **Rimantadine** by the introduction of an amino group (NH2). This is:
- Intermediate + chemical transformation → **Rimantadine** (Step 5)
**Diagrams:**
- The diagrams illustrate the molecular structures at each step of the synthesis. Solid arrows indicate the progression of each synthetic step.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F3b49abb7-22b1-43f4-8ea9-ededd2a6e7a5%2Fb5f1c841-fc93-417b-9de9-366c6dee182d%2Fcdd0iil_processed.png&w=3840&q=75)
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