What is true of the Progress Zone model? a) the length of time a cell resides in the progress zone dictates its identity along the proximodistal axis b) it is consistent with the outcome of removing the AER at successively later stages of limb development c) once a cell leaves the progress zone, its identity is established along the proximodistal axis d) cells of the progress zone are stimulated to divide by the AER e) all of the above You isolate a new mutant chicken strain in which limb outgrowth is severely curtailed.   Limbdevelopment begins and the AER initially forms, but the AER then degenerates and subsequent development of the limb is aborted.  Which of the following is a possible explanation for the AER phenotype? a) the mutant gene may function cell autonomously in the AER b) the mutant gene may function cell-nonautonomously in the limb bud mesenchyme c) the mutant gene may interfere with the feedback loop between the mesenchyme and AER d) all of the above

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