What is the strongest evidence that this is not a mitochondrial disorder (and therefore may just be dominant)? Do not many any assumptions about whether the allele is rare or not.  a. IV-1 is affected  b. II-1 is affected  c. II-2 is affected  d. III-2 is affected  e. IV-2 is unaffected.

Human Anatomy & Physiology (11th Edition)
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Chapter1: The Human Body: An Orientation
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What is the strongest evidence that this is not a mitochondrial disorder (and therefore may just be dominant)? Do not many any assumptions about whether the allele is rare or not. 

a. IV-1 is affected 

b. II-1 is affected 

c. II-2 is affected 

d. III-2 is affected 

e. IV-2 is unaffected. 

This diagram is a classic representation of a pedigree chart used in genetics to track the inheritance of traits across generations. Here’s a detailed explanation:

- **Symbols**: 
  - Squares represent males.
  - Circles represent females.
  - Filled symbols (black) indicate individuals expressing a certain trait or condition.
  - Empty symbols (white) indicate individuals without the trait.

- **Structure**:
  - The chart is organized into generations, with the top row representing the first generation and the bottom row representing the subsequent generations.
  - Horizontal lines connecting a square and a circle signify a mating couple.
  - Vertical lines leading downwards indicate offspring.

- **Generational Analysis**:
  - **First Generation**: 
    - A male without the trait mates with a female with the trait.
  - **Second Generation**: 
    - They have three children: one male with the trait, one female with the trait, and one male without the trait.
  - **Third Generation**: 
    - The trait-expressing female mates with a male with the trait, producing a female with the trait and a male without the trait.

This chart can be used to deduce the possible modes of inheritance (such as autosomal dominant or recessive) by analyzing the pattern in which the trait appears in the family.
Transcribed Image Text:This diagram is a classic representation of a pedigree chart used in genetics to track the inheritance of traits across generations. Here’s a detailed explanation: - **Symbols**: - Squares represent males. - Circles represent females. - Filled symbols (black) indicate individuals expressing a certain trait or condition. - Empty symbols (white) indicate individuals without the trait. - **Structure**: - The chart is organized into generations, with the top row representing the first generation and the bottom row representing the subsequent generations. - Horizontal lines connecting a square and a circle signify a mating couple. - Vertical lines leading downwards indicate offspring. - **Generational Analysis**: - **First Generation**: - A male without the trait mates with a female with the trait. - **Second Generation**: - They have three children: one male with the trait, one female with the trait, and one male without the trait. - **Third Generation**: - The trait-expressing female mates with a male with the trait, producing a female with the trait and a male without the trait. This chart can be used to deduce the possible modes of inheritance (such as autosomal dominant or recessive) by analyzing the pattern in which the trait appears in the family.
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