What is the probability of a hemophiliac daughter if the mother is a carrier and the father is normal? Remember hemophilia is caused by a recessive X-linked allele. 1/2 01 0 3/4 OC
What is the probability of a hemophiliac daughter if the mother is a carrier and the father is normal? Remember hemophilia is caused by a recessive X-linked allele. 1/2 01 0 3/4 OC
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Transcribed Image Text:### Probability Calculation of Hemophilic Offspring
**Question:** What is the probability of a hemophilic daughter if the mother is a carrier and the father is normal? Remember, hemophilia is caused by a recessive X-linked allele.
#### Answer Choices:
1. \( \frac{3}{4} \)
2. 0
3. 1
4. \( \frac{1}{2} \)
---
### Explanation:
**Genetics Background:**
Hemophilia is an X-linked recessive disorder, meaning it is carried on the X chromosome. Females have two X chromosomes (XX), while males have one X and one Y chromosome (XY). For a female to express hemophilia, she must inherit the hemophilia allele from both parents. However, she can be a carrier if she inherits the hemophilia allele from one parent.
**Possible Genotypes:**
- **Mother (Carrier):** X\(^H\)X\(^h\)
- **Father (Normal):** X\(^H\)Y
Where:
- X\(^H\) represents the normal allele.
- X\(^h\) represents the hemophilia allele.
**Punnett Square Analysis:**
To determine the probability of having a hemophilic daughter, we can create a Punnett Square combining the mother's X\(^H\)X\(^h\) and father's X\(^H\)Y genotypes.
| | X\(^H\) (Father) | Y (Father) |
|------|-----------------|------------|
| X\(^H\) (Mother) | X\(^H\)X\(^H\) | X\(^H\)Y |
| X\(^h\) (Mother) | X\(^H\)X\(^h\) | X\(^h\)Y |
From the Punnett Square, the possible offspring are:
- X\(^H\)X\(^H\): Normal daughter
- X\(^H\)X\(^h\): Carrier daughter
- X\(^H\)Y: Normal son
- X\(^h\)Y: Hemophilic son
**Conclusion:**
- There are no X\(^h\)X\(^h\) (hemophilic daughter) combinations in this scenario.
- Hence, the probability of
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