If the granddaughter III-1, has a girl, what is the chance that the girl will have the allele for breast cancer? 2Flg. 1. Breast cancer families 1 to7. Solid circles, females withbreast cancer; open circles, fe-males without breast cancer; opensquares, males without breastcancer. The age given for eachwoman is age at (first) breast can-cer diagnosis (dx) if affected, ageat death if deceased (deceased in-dividuals are represented by diag-onal lines through symbols), orage at most recent interview ifalive without breast cancer. Al-leles of D17S74 are shown for allfamilies and are lettered sequen-dx 44dx 45 dx 39BA 8065BD AEdx 41 dx 2339BA BEDE

Answered: Flg. 1. Breast cancer families 1 to 7.…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

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If the granddaughter III-1, has a girl, what is the chance that the girl will have the allele for breast cancer?

2
Flg. 1. Breast cancer families 1 to
7. Solid circles, females with
breast cancer; open circles, fe-
males without breast cancer; open
squares, males without breast
cancer. The age given for each
woman is age at (first) breast can-
cer diagnosis (dx) if affected, age
at death if deceased (deceased in-
dividuals are represented by diag-
onal lines through symbols), or
age at most recent interview if
alive without breast cancer. Al-
leles of D17S74 are shown for all
families and are lettered sequen-
dx 44
dx 45 dx 39
BA 80
65
BD AE
dx 41 dx 23
39
BA BE
DE

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Step 1 Explanation

Answer:-

An allele is the alternative and variant form of a gene, which is located on the same locus. It contributes to the phenotype of the organism. The allele is responsible for the phenotype based on whether it is dominant or recessive.

It is given that a female acquires an X-linked dominant mutation.
None of her parents carry the mutation. So, she must be heterozygous for the dominant mutant allele.

XD = Dominant mutant allele
Xd = WT recessive allele Genotype of the woman = XDXd Genotype of the normal man = XdY Parental cross: XDXd X XdY
Progeny: XDXd XDY XdXd XdY
The probability that her daughter is affected = 1/2
= 50%
The chance that girl will have to the allele breast cancer is 50 %.

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