Homework Help is Here – Start Your Trial Now!
Science
Biochemistry
What is the net gain in ATP for ß-oxidation of palmitic acid (a sixteen-carbon fatty acid)?

What is the net gain in ATP for ß-oxidation of palmitic acid (a sixteen-carbon fatty acid)?

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
See similar textbooks
icon
Related questions
Question

I don't get it at all. I struggled with my homework. Can you help me? Can you help me to explain to me to get the ANSWER: 107 ATP, please?

15.22) What is the net gain in ATP for ß-oxidation of palmitic acid (a sixteen-carbon fatty acid)? ANSWER: 107 ATP EXPLANATION: First, palmitic acid is activated to produce a 16-carbon fatty acyl-CoA. The activation step consumes one ATP. A 16-carbon fatty acyl-CoA will undergo seven ß-oxidation spirals. Each of the first six spirals of ß-oxidation produces one acetyl-CoA, one NADH, and one FADH₂. The final cycle of the spiral produces two acetyl-CoA, one NADH, and one FADH₂. The acetyl-CoA are processed through the citric acid cycle, producing ATP and more reduced coenzymes. The NADH, and FADH₂ formed in ß- oxidation, and the NADH, and FADH₂ formed in the citric acid cycle undergo oxidative phosphorylation. Because one ATP was consumed in the activation reaction, it is subtracted when calculating the net gain of ATP. ß- oxidation of a sixteen-carbon fatty acid, on average, results in a net gain of 107 ATP. fatty acyl-CoA with 16 carbons CH.CH.CH-CH:CH-CH:CH-CH-CHICCGBCHCH.CH.CH-COA fatty acyl-CoA with 4 carbons O For more details: See chapter 15 part 11 video or fatty acyl-CoA with 14 carbons 0 CHCHCHCH CHỊCH CH;CH,CHCH CH,CH,CHC–CoA fatty acyl-CoA with 10 carbons CH,CH,CH,CH,CH,CH,CH,CH,CH,CCOA fatty acyl-CoA with 12 carbons CH,CH,CH,CH,CH,CH,CH,CH,CH,CH,CH,C—Cos fatty acyl-CoA with 8 carbons CH,CH,CH,CH,CH,CH,CH,C—CaA acetyl-CoA fatty acyl-CoA with 6 carbons CH₂CH₂CH₂CH₂CH₂C CH₂CH₂CH₂C-CoA 0 -‒‒‒‒‒ Total: 8 acetyl-CoA Citric Acid Cycle Subtract one ATP that was used in the activation reaction 8 ATP 22.5 ATP 77.5 ATP -1 ATP acetyl-CoA FADH₂ acetyl-CoA FADH₂ + NADH NADH acetyl-CoA+FADH₂ + NADH acetyl-CoA+FADH₂ + NADH acetyl-CoA+ FADH₂ + NADH acetyl-CoA+ FADH₂ NADH acetyl-CoA FADH₂ + NADH Oxidative Phosphorylation 1.5 ATP 1 FADH₂ 2.5 ATP 1 NADH 8 FADH₂ + 24 NADH Totals: 15 FADH₂ 31 NADH
Transcribed Image Text:15.22) What is the net gain in ATP for ß-oxidation of palmitic acid (a sixteen-carbon fatty acid)? ANSWER: 107 ATP EXPLANATION: First, palmitic acid is activated to produce a 16-carbon fatty acyl-CoA. The activation step consumes one ATP. A 16-carbon fatty acyl-CoA will undergo seven ß-oxidation spirals. Each of the first six spirals of ß-oxidation produces one acetyl-CoA, one NADH, and one FADH₂. The final cycle of the spiral produces two acetyl-CoA, one NADH, and one FADH₂. The acetyl-CoA are processed through the citric acid cycle, producing ATP and more reduced coenzymes. The NADH, and FADH₂ formed in ß- oxidation, and the NADH, and FADH₂ formed in the citric acid cycle undergo oxidative phosphorylation. Because one ATP was consumed in the activation reaction, it is subtracted when calculating the net gain of ATP. ß- oxidation of a sixteen-carbon fatty acid, on average, results in a net gain of 107 ATP. fatty acyl-CoA with 16 carbons CH.CH.CH-CH:CH-CH:CH-CH-CHICCGBCHCH.CH.CH-COA fatty acyl-CoA with 4 carbons O For more details: See chapter 15 part 11 video or fatty acyl-CoA with 14 carbons 0 CHCHCHCH CHỊCH CH;CH,CHCH CH,CH,CHC–CoA fatty acyl-CoA with 10 carbons CH,CH,CH,CH,CH,CH,CH,CH,CH,CCOA fatty acyl-CoA with 12 carbons CH,CH,CH,CH,CH,CH,CH,CH,CH,CH,CH,C—Cos fatty acyl-CoA with 8 carbons CH,CH,CH,CH,CH,CH,CH,C—CaA acetyl-CoA fatty acyl-CoA with 6 carbons CH₂CH₂CH₂CH₂CH₂C CH₂CH₂CH₂C-CoA 0 -‒‒‒‒‒ Total: 8 acetyl-CoA Citric Acid Cycle Subtract one ATP that was used in the activation reaction 8 ATP 22.5 ATP 77.5 ATP -1 ATP acetyl-CoA FADH₂ acetyl-CoA FADH₂ + NADH NADH acetyl-CoA+FADH₂ + NADH acetyl-CoA+FADH₂ + NADH acetyl-CoA+ FADH₂ + NADH acetyl-CoA+ FADH₂ NADH acetyl-CoA FADH₂ + NADH Oxidative Phosphorylation 1.5 ATP 1 FADH₂ 2.5 ATP 1 NADH 8 FADH₂ + 24 NADH Totals: 15 FADH₂ 31 NADH
Expert Solution
steps

Step by step

Solved in 3 steps

SEE SOLUTIONCheck out a sample Q&A here
Blurred answer
Recommended textbooks for you
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman
Lehninger Principles of Biochemistry
Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul…
Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305961135
Author:
Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:
Cengage Learning
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305577206
Author:
Reginald H. Garrett, Charles M. Grisham
Publisher:
Cengage Learning
Fundamentals of General, Organic, and Biological …
Fundamentals of General, Organic, and Biological …
Biochemistry
ISBN:
9780134015187
Author:
John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:
PEARSON
SEE MORE TEXTBOOKS