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- Why does Glutathione have a low bioavailability when applied topically?Explain the chemical change that occurs in converting kynurenine (a product of tryptophan degradation) to kynurenate, a reaction in which α-ketoglutarate is transformed to glutamate.What is the difference between steroidal and nonsteroidal aromatase inhibitors? which one is better for postmenopausal women and why? Explain in detail.
- The aminoacids, phenylalanine and tyrosine, are degraded to acetoac- etate and fumarate by a single pathway. Name the diseases related to this pathway.What is the underlying mechinism of action for the antibiotic Trimethoprin/sulfamethoxazole (SXT)?Are there any amino acids involved in the synthesis of protoporphyrin IX?
- Write a mechanism for the formation of acetoin from acetolactate using acetolactate synthase.6-Mercaptopurine , after its conversion to the corresponding nucleotide through salvage reactions, is a potent competitive inhibitor of IMP in the pathways for AMP and GMP biosynthesis. It is therefore a clinically useful anticancer agent. The chemotherapeutic effectiveness of 6 mercaptopurine is enhanced when it is administered with allopurinol. Explain the mechanism of this enhancement.A patient with H. pylori infection develops a gastric ulcer and is treated with omeprazole. Which of the following is/are mechanism(s) of action of omeprazole? Group of answer choices Inhibition of ACh action on parietal cells stimulation of somatostatin action on parietal cells inhibition of CCKb receptors inhibition of H+-K+ ATPase inhibition of Na+-K+ ATPase.