What is the centromere of a chromosome?
What is the centromere of a chromosome?
The centromere is the specialized DNA arrangement of a chromosome that interfaces a pair of sister chromatids (a dyad). During mitosis, shaft strands attach to the centromere via the kinetochore. Centromeres were first idea to be genetic loci that direct the behavior of chromosomes.
The physical role of the centromere is to act as the site of assembly of the kinetochores – a profoundly unpredictable multiprotein structure that is liable for the actual occasions of chromosome segregation – for example restricting microtubules and signaling to the phone cycle machinery when all chromosomes have adopted right attachments to the axle, so it is safe for cell division to continue to culmination and for cells to enter anaphase.
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