What is the approximate membrane potential (mV) when the neuron is ready to be "fired"?

Assume a length of axon membrane of about 0.10 m is excited by an action potential (length excited = nerve speed pulse duration = 50.0 m/s 2.0 103 s = 0.10 m). In the resting state, the outer surface of the axon wall is charged positively with K+ ions and the inner wall has an equal and opposite charge of negative organic ions, as shown in Figure P18.43. Model the axon as a parallel-plate capacitor and take C = 0A/d and Q = C V to investigate the charge as follows. Use typical values for a cylindrical axon of cell wall thickness d = 1.0 108 m, axon radius r = 1.0 101 m, and cell-wall dielectric constant = 3.0. (a) Calculate the positive charge on the outside of a 0.10-m piece of axon when it is not conducting an electric pulse. How many K+ ions are on the outside of the axon assuming an initial potential difference of 7.0 102 V? Is this a large charge per unit area? Hint: Calculate the charge per unit area in terms of electronic charge e per squared (2). An atom has a cross section of about 1 2 (1 = 1010 m). (b) How much positive charge must flow through the cell membrane to reach the excited state of + 3.0 102 V from the resting state of 7.0 102 V? How many sodium ions (Na+) is this? (c) If it takes 2.0 ms for the Na+ ions to enter the axon, what is the average current in the axon wall in this process? (d) How much energy does it take to raise the potential of the inner axon wall to + 3.0 102 V, starting from the resting potential of 7.0 102 V? Figure P18.43 Problem 43 and 44.

Try to complete Table P26.5 from memory. If you must look back in the chapter for information, note the page number, figure number, or equation number that helped you. TABLE P26.5

(a) Suppose that a person has an average heart rate of 72.0 beats/min. How many beats does he or she have in 2.0 y? (b) In 2.00 y? (c) In 2.000 y?