what intermolecular forces between the interaction of A475 and S19

Introduction to General, Organic and Biochemistry
11th Edition
ISBN:9781285869759
Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Chapter22: Proteins
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what intermolecular forces between the interaction of A475 and S19
1. As you can see in Fig. 1(C), there is an interaction between A475 on SARS-CoV-2 and S19
on ACE-2. A475 is the amino acid alanine, and S19 is serine. Remember, amino acids
form chains through a condensation reaction, as illustrated here:
https://chem.libretexts.org/Bookshelves/Introductory Chemistry/Introductory Chemist
ry (CK-12)/25%3A Organic Chemistry/25.18%3A Condensation Reactions). Here are
those structures, from Wikipedia:
*Copy/paste the link into your browser*
Alanine
Serine
H3C.
`OH
но
ÑH2
NH2
Skeletal formula of L-
Skeletal formula of L-alanine
serine
Ball-and-stick model
Space-filling model
Ball-and-stick model
Space-filling model
The blue portions of the structure represent nitrogen atoms, and the red portions represent
oxygen. The same is true in Figures 1 and 2 in the paper. This interaction is noted to be new to
SARS-COV-2 compared to SARS-CoV and is a key finding in explaining how the behaviors of
these viruses differ. What kind of interactions could be occurring between A475 and S19? Mark
all that apply.
A. Dipole-dipole
B. London dispersion
C. lon-ion
D. Hydrogen bond
Transcribed Image Text:1. As you can see in Fig. 1(C), there is an interaction between A475 on SARS-CoV-2 and S19 on ACE-2. A475 is the amino acid alanine, and S19 is serine. Remember, amino acids form chains through a condensation reaction, as illustrated here: https://chem.libretexts.org/Bookshelves/Introductory Chemistry/Introductory Chemist ry (CK-12)/25%3A Organic Chemistry/25.18%3A Condensation Reactions). Here are those structures, from Wikipedia: *Copy/paste the link into your browser* Alanine Serine H3C. `OH но ÑH2 NH2 Skeletal formula of L- Skeletal formula of L-alanine serine Ball-and-stick model Space-filling model Ball-and-stick model Space-filling model The blue portions of the structure represent nitrogen atoms, and the red portions represent oxygen. The same is true in Figures 1 and 2 in the paper. This interaction is noted to be new to SARS-COV-2 compared to SARS-CoV and is a key finding in explaining how the behaviors of these viruses differ. What kind of interactions could be occurring between A475 and S19? Mark all that apply. A. Dipole-dipole B. London dispersion C. lon-ion D. Hydrogen bond
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