What conjugate base must be formed during the E1cb mechansim in an aldol condensation reaction running under basic conditions? O A. enol B. · B-hydroxy carbonyl C. a,B-unsaturated carbonyl enolate

Q: 1) PhN=C=S; 2) HF CF3CO2H HF 1) DCC; 2) HF NaOH, H2O 1) DCC; 2) CF3CO2H 1) DCC; 2) NaOH PhN=C=S DCC

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Q: Enolate Chemistry PS 2: Aldol Reactions B H. D Ph. H. Ph. H.

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Q: 4.a. Show the mechanism for the following Claisen rearrangement. b. Provide the product for the…

A: To find out the product and mechanism of the given reaction

Q: What is the major elimination product expected from the following reaction? Br. NaOMe MeOH Select…

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A: Step 1: Step 2: Step 3: Step 4:

Q: OA OB 6. The mechanism for this reaction is: A. SN2 B. Hydration C. SN1 D. Dehydration OC Br D ΚΙ…

A: An arrow always depicts from a region of high electron density to low electron density ; that is…

Q: 9. What is the correct product of the acid treatment of the B-hydroxy ketone shown below? OH CH3 a.…

A: The given reaction is rearrangement of -hydroxy ketone in acid.

Q: 2) Draw the mechanism and the product(s) for the following: Aldol condensation reaction H3C CH3 H OH

A: In aldol condensation reaction two molecules of aldehyde containing at least one alpha hydrogen atom…

Q: 8. Using the Enamines as nucleophiles, draw the final product. N-H H*

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Q: What is the Aldol condensation product for the following reaction? OH O cool.ntu.edu.tw NaOH

A: Thank you.

Q: What cyclic product is formed from each dihalide using the malonic ester synthesis?

A: Formation of cyclic product: The base attacks the alpha-hydrogen of diethyl malonate.  A nucleophile…

Q: 5. Which of the following compounds will not undergo Aldol reaction and why? `H `H а. b. CH3 с. d.…

A: If adjacent carbon of carbonyl carbon contain alpha hydrogen (sp3 hybridised) then undergo aldol…

Q: Select the product(s) formed in the following crossed aldol reaction. CH3CH₂CH₂CHO C. E. CHO OH CHO…

A: Aldol condensation is condensation between two molecules of aldehyde or ketone in presence of base…

Q: What types of species are the electrophile and nucleophile in an aldol addition? 1. Nu: ester, E+:…

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Q: Whether increase or decrease rate of aldol reaction: a. Additional substitution on the ketone b.…

A: Aldol reaction is reaction of carbonyl compound in which first of all nucleophile formed then there…

Q: 4. Draw the product(s) of each epoxide opening reaction a. b. O a. NaOCH 3, THE b. H₂O HBr

A: (a) Nucleophile attack on less substituted carbon.(b) Nucleophile attack on more substituted…

Q: A-D please! Thank you so much!

A: 3. We have to draw the structure of the major products when 3-hexyne treated with the given…

Q: What is the effect of halving the amount of 2-bromo-2-methylpropa Br HO, heat O a. the reaction rate…

A: The unimolecular substitution reactions are abbreviated as SN1. In this reaction, the…

Q: Identify the compound that forms the following acetal upon treating with acid and removing water. O…

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Q: Draw the major product of this aldol addition reaction. Ignore inorganic byproducts. 1. LDA 2.…

A: The objective of this question is to draw the products for the given reaction.

Q: Provide the product and/or type of the reaction necessary for the following transformations.…

A: The question is based on organic reactions.We need to identify the product and explain its…

Q: A 4. What is the major product of the following intramolecular aldol condensation reaction? NaOH H20…

A: In this question we have to tell the product of the reaction.

Q: QUOD 30 balabibul noite Describe the mechanism of the following Claisen reaction Question 7 R -OH H…

A: Reaction between two esters or one ester and another carbonyl compound in the presence of a strong…

Reactions at the Alpha Carbon Atom

The position next to the ketone or aldehyde functional group is termed as alpha position and the reaction which occurs at alpha position is called alpha substitution reaction. In an alpha substitution reaction, the alpha proton atom is substituted by an electrophile by the formation of an enol intermediate or enolate ion intermediate. Most of the carbonyl compounds go through an alpha substitution reaction.