What conjugate base must be formed during the E1cb mechansim in an aldol condensation reaction running under basic conditions? O A. enol B. · B-hydroxy carbonyl C. a,B-unsaturated carbonyl enolate

Q: 1) PhN=C=S; 2) HF CF3CO2H HF 1) DCC; 2) HF NaOH, H2O 1) DCC; 2) CF3CO2H 1) DCC; 2) NaOH PhN=C=S DCC

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Q: Enolate Chemistry PS 2: Aldol Reactions B H. D Ph. H. Ph. H.

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Q: Convert each compound to its enol or keto tautomer. a. CH3 CH3 b. OH

A: Since you have asked multiple questions, we will solve the first question for you. If you want any…

Q: 4.a. Show the mechanism for the following Claisen rearrangement. b. Provide the product for the…

A: To find out the product and mechanism of the given reaction

Q: What is the major elimination product expected from the following reaction? Br. NaOMe MeOH Select…

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A: Step 1: Step 2: Step 3: Step 4:

Q: 11. OMe Me

A: Step 1 : Birch reduction. Step 2 : reaction with acid Step 3 : C-alkylation. Step 4 : Robinson…

Q: 14. The compound below is treated with excessive amount of each reagent. Draw the products for…

A: The given molecule is multi-functional. The reacts of such molecules are always challenging from…

Q: OA OB 6. The mechanism for this reaction is: A. SN2 B. Hydration C. SN1 D. Dehydration OC Br D ΚΙ…

A: An arrow always depicts from a region of high electron density to low electron density ; that is…

Q: Draw the product formed from an aldol reaction with the given starting material(s) using OH, H,C. a.…

A: The carbanion formed by the abstraction of proton by the OH- ions on the 2-methyl propanal, is less…

Q: 5) Which of the indicated eliminations is easier? -HCI -HBr R Br H2SO, -HI T -H,0 6) Which of the…

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Q: 9. What is the correct product of the acid treatment of the B-hydroxy ketone shown below? OH CH3 a.…

A: The given reaction is rearrangement of -hydroxy ketone in acid.

Q: 2) Draw the mechanism and the product(s) for the following: Aldol condensation reaction H3C CH3 H OH

A: In aldol condensation reaction two molecules of aldehyde containing at least one alpha hydrogen atom…

Q: 8. Using the Enamines as nucleophiles, draw the final product. N-H H*

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Q: What is the Aldol condensation product for the following reaction? OH O cool.ntu.edu.tw NaOH

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Q: What cyclic product is formed from each dihalide using the malonic ester synthesis?

A: Formation of cyclic product: The base attacks the alpha-hydrogen of diethyl malonate.  A nucleophile…

Q: 20. Which base(s) listed below would be used for an aldol reaction? a. LDA b. NaH c. NaOEt d. Both…

A: An aldol reaction is a type of organic reaction that involves the formation of a new carbon-carbon…

Q: 5. Which of the following compounds will not undergo Aldol reaction and why? `H `H а. b. CH3 с. d.…

A: If adjacent carbon of carbonyl carbon contain alpha hydrogen (sp3 hybridised) then undergo aldol…

Q: Select the product(s) formed in the following crossed aldol reaction. CH3CH₂CH₂CHO C. E. CHO OH CHO…

A: Aldol condensation is condensation between two molecules of aldehyde or ketone in presence of base…

Q: What types of species are the electrophile and nucleophile in an aldol addition? 1. Nu: ester, E+:…

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Q: What cyclic product is formed from each dihalide using the malonic ester synthesis?

A: By using malonic ester synthesis, substituted carboxylic acids can be synthesised. In this reaction,…

Q: Whether increase or decrease rate of aldol reaction: a. Additional substitution on the ketone b.…

A: Aldol reaction is reaction of carbonyl compound in which first of all nucleophile formed then there…

Q: 15. Which of the following would react fastest in an elimination reaction using NaOMe/MeOH? First…

A: Here elimination reaction will take place and Naome is common base for all. So will we see leaving…

Q: 4. Draw the product(s) of each epoxide opening reaction a. b. O a. NaOCH 3, THE b. H₂O HBr

A: (a) Nucleophile attack on less substituted carbon.(b) Nucleophile attack on more substituted…

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A: 3. We have to draw the structure of the major products when 3-hexyne treated with the given…

Q: 39. Predict the four possible Aldol condensation products and their dehydration products. KOH, H20.…

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Q: What is the effect of halving the amount of 2-bromo-2-methylpropa Br HO, heat O a. the reaction rate…

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Q: Using cyclopentanone as the reactant, show the product of a. acid-catalyzed keto–enol…

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Q: Identify the compound that forms the following acetal upon treating with acid and removing water. O…

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Q: Jlain, why organocopper reagents are weaker nucleophile in comparison to organocuprate reagents.

A: Nucleophile are the chemical species that forms bond with the electrophile by donating it's lone…

Q: 59. Devise a synthesis of each epoxides (B and C) from the alcohol A. a OH क़ B A

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Q: What alkene can be used to prepare each alcohol as the exclusive product of a two-step…

A: Hydroboration oxidation is an oxidation reaction of alcohols which convert alkenes to alcohol by…

Q: Draw the major product of this aldol addition reaction. Ignore inorganic byproducts. 1. LDA 2.…

A: The objective of this question is to draw the products for the given reaction.

Q: Provide the product and/or type of the reaction necessary for the following transformations.…

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Q: C. any additional reagent Show one different routes in the Grignard Reaction OH The

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Q: 4.The following two molecules undergo stereospecific eliminations reactions. Draw the expected…

A: Detail mechanistic pathway is given below to find out the product

Q: A 4. What is the major product of the following intramolecular aldol condensation reaction? NaOH H20…

A: In this question we have to tell the product of the reaction.

Q: Draw ALL possible elimination products and choose the one most likely formed and explain the reason.…

A: Here we have to predict the major product and possible elimination products obtained by the…

Q: 18. Which reactions yield B-ketoesters as products? a. Acetoacetic Ester Synthesis b. Malonic Ester…

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Q: QUOD 30 balabibul noite Describe the mechanism of the following Claisen reaction Question 7 R -OH H…

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Reactions at the Alpha Carbon Atom

The position next to the ketone or aldehyde functional group is termed as alpha position and the reaction which occurs at alpha position is called alpha substitution reaction. In an alpha substitution reaction, the alpha proton atom is substituted by an electrophile by the formation of an enol intermediate or enolate ion intermediate. Most of the carbonyl compounds go through an alpha substitution reaction.