WDANIKQRLSTEYKQ (a) How many full turns are in this a-helix? (b) What is the length of the helix (in Angströms) in the direction of the helix axis? (c) How many hydrogen bonds between the backbone atoms are in this helix? Explain your reasoning. (d) In the protein, one side of this helix is facing the hydrophobic core of the protein, and the other side is facing the aqueous solvent. Circle the residues involved in the hydrophobic contacts. Underline those residues that favor contacts with water. (e) What would you predict the effect of each of the following mutations to be on the stability of the helix? Explain your reasoning. 1. I->A 2. R->A 3. E->R 4. W->P

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4. *** Consider an a-helix with the following sequence: 

WDANIKQRLSTEYKQ
(a) How many full turns are in this a-helix?
(b) What is the length of the helix (in Angströms) in the direction of the helix axis?
(c) How many hydrogen bonds between the backbone atoms are in this helix?
Explain your reasoning.
(d) In the protein, one side of this helix is facing the hydrophobic core of the
protein, and the other side is facing the aqueous solvent. Circle the residues
involved in the hydrophobic contacts. Underline those residues that favor
contacts with water.
(e) What would you predict the effect of each of the following mutations to be on
the stability of the helix? Explain your reasoning.
1. I->A
2. R->A
3. E->R
4. W->P
Transcribed Image Text:WDANIKQRLSTEYKQ (a) How many full turns are in this a-helix? (b) What is the length of the helix (in Angströms) in the direction of the helix axis? (c) How many hydrogen bonds between the backbone atoms are in this helix? Explain your reasoning. (d) In the protein, one side of this helix is facing the hydrophobic core of the protein, and the other side is facing the aqueous solvent. Circle the residues involved in the hydrophobic contacts. Underline those residues that favor contacts with water. (e) What would you predict the effect of each of the following mutations to be on the stability of the helix? Explain your reasoning. 1. I->A 2. R->A 3. E->R 4. W->P
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