Homework Help is Here – Start Your Trial Now!
Science
Biology
w that although he has clinical findings of CF, his eat chloride concentration is normal. The sweat chlo- e concentration is normal in less than 2% of patients h CF. His pediatrician and parents want to know if A analysis can determine whether he indeed has CF. Would DNA analysis be useful in this case? Briefly outline the steps involved in obtaining a DNA diag- nosis for CF. If he has CF, what is the probability that he is homo- zygous for the AF508 mutation? (Assume that 85% of CF mutations could be detected at the time you are consulted and that his parents are from northern Europe, where the AF508 allele has a frequency of 0.70.) If he does not have the AF508 mutation, does this disprove the diagnosis? Explain.

w that although he has clinical findings of CF, his eat chloride concentration is normal. The sweat chlo- e concentration is normal in less than 2% of patients h CF. His pediatrician and parents want to know if A analysis can determine whether he indeed has CF. Would DNA analysis be useful in this case? Briefly outline the steps involved in obtaining a DNA diag- nosis for CF. If he has CF, what is the probability that he is homo- zygous for the AF508 mutation? (Assume that 85% of CF mutations could be detected at the time you are consulted and that his parents are from northern Europe, where the AF508 allele has a frequency of 0.70.) If he does not have the AF508 mutation, does this disprove the diagnosis? Explain.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
See similar textbooks
icon
Related questions
Question
Johnny, 2 years of age, is failing to thrive. Investigations show that although he has clinical findings of CF, his sweat chloride concentration is normal. The sweat chlo- ride concentration is normal in less than 2% of patients with CF. His pediatrician and parents want to know if DNA analysis can determine whether he indeed has CF. a. Would DNA analysis be useful in this case? Briefly outline the steps involved in obtaining a DNA diag- nosis for CF. b. If he has CF, what is the probability that he is homo- zygous for the AF508 mutation? (Assume that 85% of CF mutations could be detected at the time you are consulted and that his parents are from northern Europe, where the AF508 allele has a frequency of 0.70.) c. If he does not have the AF508 mutation, does this disprove the diagnosis? Explain.
Transcribed Image Text:Johnny, 2 years of age, is failing to thrive. Investigations show that although he has clinical findings of CF, his sweat chloride concentration is normal. The sweat chlo- ride concentration is normal in less than 2% of patients with CF. His pediatrician and parents want to know if DNA analysis can determine whether he indeed has CF. a. Would DNA analysis be useful in this case? Briefly outline the steps involved in obtaining a DNA diag- nosis for CF. b. If he has CF, what is the probability that he is homo- zygous for the AF508 mutation? (Assume that 85% of CF mutations could be detected at the time you are consulted and that his parents are from northern Europe, where the AF508 allele has a frequency of 0.70.) c. If he does not have the AF508 mutation, does this disprove the diagnosis? Explain.
Expert Solution
steps

Step by step

Solved in 5 steps

SEE SOLUTIONCheck out a sample Q&A here
Blurred answer
Knowledge Booster
Protozoan infections
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.
Similar questions
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:
9780815344322
Author:
Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:
W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:
9781260159363
Author:
Martin, Terry R., Prentice-craver, Cynthia
Publisher:
McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Inquiry Into Life (16th Edition)
Biology
ISBN:
9781260231700
Author:
Sylvia S. Mader, Michael Windelspecht
Publisher:
McGraw Hill Education
SEE MORE TEXTBOOKS