Viruses with negative sense RNA genomes typically, make proteins by: (Ignore retroviruses, and the unusual characteristics of coronaviruses) Translation of short RNA transcripts generated by RDRP Generating a DNA copy, which is then transcribed by host RNA polymerase. Translation of the viral genome by host ribosomes. Production of a polyprotein, which must be cleaved into smaller proteins. Generating a negative sense genome copy, which is then translated by host ribosomes.

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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**Transcription for Educational Website:**

**Title:** Protein Synthesis in Viruses with Negative Sense RNA Genomes

**Description:** Learn the typical mechanisms used by viruses with negative sense RNA genomes to produce proteins. This guide excludes retroviruses and the unique characteristics of coronaviruses.

**Mechanisms:**

- □ Translation of short RNA transcripts generated by RDRP (RNA-dependent RNA polymerase).
- □ Generating a DNA copy, which is then transcribed by host RNA polymerase.
- □ Translation of the viral genome by host ribosomes.
- □ Production of a polyprotein, which must be cleaved into smaller proteins.
- □ Generating a negative sense genome copy, which is then translated by host ribosomes.

**Visual Aids:** Diagrams or illustrations may be included to visually represent these mechanisms, enhancing understanding through step-by-step visual descriptions.
Transcribed Image Text:**Transcription for Educational Website:** **Title:** Protein Synthesis in Viruses with Negative Sense RNA Genomes **Description:** Learn the typical mechanisms used by viruses with negative sense RNA genomes to produce proteins. This guide excludes retroviruses and the unique characteristics of coronaviruses. **Mechanisms:** - □ Translation of short RNA transcripts generated by RDRP (RNA-dependent RNA polymerase). - □ Generating a DNA copy, which is then transcribed by host RNA polymerase. - □ Translation of the viral genome by host ribosomes. - □ Production of a polyprotein, which must be cleaved into smaller proteins. - □ Generating a negative sense genome copy, which is then translated by host ribosomes. **Visual Aids:** Diagrams or illustrations may be included to visually represent these mechanisms, enhancing understanding through step-by-step visual descriptions.
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