Vinblastine is a standard chemotherapeutic drug used to treatcancer. Because it interferes with the assembly of microtubules,its effectiveness must be related to(A) disruption of mitotic spindle formation.(B) suppression of cyclin production.(C) myosin denaturation and inhibition of cleavage furrowformation.(D) inhibition of DNA synthesis.

Vinblastine is a standard chemotherapeutic drug used to treatcancer. Because it interferes with the assembly of microtubules,its effectiveness must be related to(A) disruption of mitotic spindle formation.(B) suppression of cyclin production.(C) myosin denaturation and inhibition of cleavage furrowformation.(D) inhibition of DNA synthesis.

Human Biology (MindTap Course List)

11th Edition

ISBN:9781305112100

Author:Cecie Starr, Beverly McMillan

Publisher:Cecie Starr, Beverly McMillan

Chapter22: Genes And Disease: Cancer

Section: Chapter Questions

Problem 1RQ

See similar textbooks

Related questions

Q: How did you know that Paclitaxel was inhibiting cell division? What method of observation was used…

A: The investigation into the effects of Paclitaxel on cell division is a critical aspect of cancer…

Q: There are certain cells that are multinucleated (having more than one nucleus). Which of the…

A: Cell division is the process by which the cells of a living organism multiply and increase in number…

Q: In the brain, Alzheimers disease is linked to accumulation of a) amyloid plaques outside cells and…

A: Alzheimer's disease is a progressive neurodegenerative disorder that affects the brain, causing…

Q: Characterize the differences between tumor cells and normal cells in terms of the following…

A: A. The normal cell shows contact inhibition that means when two cells get contact then the growth…

Q: Part A and B A. What is the normal function of the Rb protein? A) Rb prevents the cell cycle from…

A: Answer A) Rb is Retinoblastoma protein which is a tumor suppressor protein and belongs to pocket…

Q: Which is true for cancer cells: 1) Cell death occurs after a determined number of cell divisions…

A: Cancer are one of the main causes of death due to chronic failure of organs such as stomach, lungs…

Q: Rb and Ink4 Cdk inhibitors are able to slow cell cycle progression. a) True Ob) False

A: Some series of steps in which the chromosome and cell materials are double to make copies are known…

Q: Some cancer drugs stop cell division by stabilizing microtubules so they cannot come apart. Which…

A: Cancer is defined as the uncontrolled and unregulated growth of the aberrant cells in an area of the…

Q: 12) Match the cell-cell junction on the left with the appropriate function on the right. Note that…

A: A)Gap junctions : these are the intercellular connections in between the cells, which connects the…

Q: A Patients with an inherited cancer have a mutation in a zinc-finger motif of P21 (a cell-cycle…

A: Each organism's DNA sequence is unique. Its base-pair sequence might vary from time to time. It is…

Q: The somatic stem cells are derived from source such as_________.a) Bone marrow, embryos, amniotic…

A: Somatic stem cells, also known as adult stem cells are undifferentiated cells that are found in the…

Q: If the mitotic spindle does not correctly attach to chromosome kinetochores, the spindle assembly…

A: Cell cycle is the process by which cell cell grows in size and divides into daughter cells Types of…

Q: Which of the following is an example of cells undergoing mitosis and cytokinesis? A) dead skin cells…

A: Mitosis is a process of cell division, in which one cell gets divided and produces two cells. These…

Q: Explain why it has to be different, and b) briefly describe the processes in the two different cell…

A: Cytokinesis is the division of the cytoplasm and is a subpart of a large process called cell…

Q: In the accelerated phase, cells begin to... A) Increases and the rate of division increases until it…

A: Characteristics of microbial growth phases. The phases of growth are based on the rate of change of…

Q: Metabolic and developmental functions in a Paramecium are regulated by genes contained in the… A)…

A: Answer : Metabolic and developmental functions in a Paramecium are regulated by genes contained in…

Q: Tamoxifen acts as a ............. pharmaceutical agent: a)Estrogen receptor–blocking…

A: tamoxifen are antiestrogens and which is a prescribed drug for breast cancer.

Q: Biopsies from aggressive cancers often have cells that contain several nuclei per cell when viewed…

A: Cancer is the stage of uncontrolled cell division.

Q: What statement about Cdks/Cyclins below is false? A) Cyclins phosphorylate Cdks B) Cdks are kinases…

A: Cell cycle includes two phases; interphase and M phase. Interphase includes G1, S and G2 phases. In…

Q: A. What below would be likely to lead to cancer development? A) Overexpression of a cell cycle…

A: Overexpression of RTK (Receptor Tyrosine Kinase) leads to the increased local concentration of the…

Q: Amount of DNA per nucleus over the cell division cycle. At which point in the accompanying…

A: When a cell splits into 2 or more new cells, this process is called cell division. The division of…

Q: Which of the following regarding microtubules is LEAST correct? A)Microtubules do not have important…

A: Microtubules are long filaments made up of protein "tubulin". They play several important roles in…

Q: Which of the following is true with respect to cyclins and CDKs? A) CDKs promote progression of the…

A: The duplication of the chromosomes takes place during the S-phase of the cell cycle. This is…

Q: . The decline of MPF activity at the end of mitosis is due to(A) the destruction of the protein…

A: It is maturation-promoting factor or mitosis promoting factor or M-Phase promoting factor. It is the…

Question

Vinblastine is a standard chemotherapeutic drug used to treat
cancer. Because it interferes with the assembly of microtubules,
its effectiveness must be related to
(A) disruption of mitotic spindle formation.
(B) suppression of cyclin production.
(C) myosin denaturation and inhibition of cleavage furrow
formation.
(D) inhibition of DNA synthesis.

Expert Solution

This question has been solved!

Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.

This is a popular solution!

SEE SOLUTION Check out a sample Q&A here

Step 1

VIEW

Step 2

VIEW

Step 3

VIEW

Trending now

This is a popular solution!

Step by step

Solved in 3 steps

SEE SOLUTION Check out a sample Q&A here

Knowledge Booster

Learn more about

Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.

Similar questions

Growth factors induce synthesis of cyclin D and then Cyclin D promotes Cdk4 and Cdk6 which progress the cell from G1 to S phase. a) True b) False
When some cancer cells produce growth factors that stimulate their own division leading to continuous self- stimulation for cell division it is referred to as a) TNF tumor necrosis factor b) AGS autocrine growth stimulation
Some cancer drugs stop cell division by stabilizing microtubules so they cannot come apart. Which step of the mitosis is disrupted? A) Telophase B) cytokinesis C) Anaphase D) Metaphase
Which of the following regarding microtubules is LEAST correct? A)Microtubules do not have important functions in neurons B)Microtubules are important for anterograde axoplasmic transport C)No answer text provided. D)Microtubules are important for maintaining the structure of the neuron E)Microtubules are important for retrograde axoplasmic transport
Part A and B A. What below would be likely to lead to cancer development? A) Overexpression of a cell cycle checkpoint inhibitor B) Loss of expression of a growth factor that promotes cell cycle entry C) Overexpression of a receptor tyrosine kinase that promotes cell cycle entry D) Overexpression of a DNA damage repair enzyme E) Loss of expression of a regulatory transcription factor that activates transcription of a cyclin B. Taxols inhibit the proper function of microtubules and are frequently used as chemotherapy drugs. What is the function of microtubules during the cell cycle? A) They promote the G1 to S checkpoint B) They normally inhibit M phase from being completed C) They form the mitotic spindle E) They mediate DNA replication F) They form the cleavage furrow during cytokinesis
Which is true for cancer cells: 1) Cell death occurs after a determined number of cell divisions 2) Contact with other cells reduces chance of cell division 3) Cell division occurs in the presence of stop signals.
1) capZ encourages the elongation of actin filaments (true or false) 2)microtubules are tissue specific (true or false ) 3) microtubule-associated proteins stabilize microtubules along their length (true or false)
3) Examine the graph showing the relative percentage normal and cancer cells spend in various stages of the cell cycle. Based on the information in the graphs, infer how cancer cells differ from typical, noncancerous cells. Select ALL that apply. A) Cancer cells do not replicate their DNA. B) Cancer cells replicate their DNA too quickly. C) Cancer cells do not go through interphase during their cell cycle. D) Cancer cells spend more time dividing compared to typical cells. E) Cancer cells do not always grow to the same size as typical cells. more than 1 answer. not graded
Biopsies from aggressive cancers often have cells that contain several nuclei per cell when viewed through a microscope. Which scenario could explain how such a multinucleated cell might have come to be? (a) The cell underwent repeated mitosis with simultaneous cytokinesis. (b) The cell had multiple S phases before it entered mitosis. (c) The cell underwent repeated mitosis, but cytokinesis did not occur. (d) The cell underwent repeated cytokinesis but no mitosis. (e) The cell actually went through meiosis and not mitosis.
Which of the following is true with respect to cyclins and CDKs? A) CDKs promote progression of the cell cycle, cyclins function to inhibit progression of the cell cycle B) CDKs are the checkpoints in the cell cycle, and when bound to cyclins, they stop progression of the cell cycle C) CDKs will only work to promote progression of the cell cycle when complexed with their designated cyclins D) CDKs are rarely expressed during a cell's cycle, unless cyclins are present to act as transcription factors .
Cytokinesis in plant cells is different than cytokinesis in animal cells. a) Explain why it has to be different, andb) briefly describe the processes in the two different cell types.
Need help If the mitotic spindle does not correctly attach to chromosome kinetochores, the spindle assembly checkpoint will be activated. Select all correct outcomes for chromosomes not correctly attached to mitotic spindle A) centrosome duplication will not occur B) M cyclin will be degraded C) APC will be inhibited D) chromosomes will not segregate E) Mad2 will bind to unattached kinetochores F) mitosis will halt at metaphase/anaphase transition