Use selected reagents provided below to perform the following reaction. Show intermediates steps along the way for full credit. 25. CH3ONa in CH3OH NaBH4 in EtOH BH3/THF PCC in CH₂Cl2 X PhLi in Et₂O 03 in CH2Cl2 H3PO4 and heat H₂O2/NaOH
Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
![### Organic Chemistry Reaction Problem
#### Problem Statement
**Question 25:** Use the selected reagents provided below to perform the following reaction. Show intermediate steps along the way for full credit.
**Reaction Scheme:**
- Reactant: Cyclohexene (a six-membered ring with one double bond)
- Product: Cyclohexanone (a six-membered ring with a ketone group)
**Available Reagents:**
1. Sodium Methoxide (CH₃ONa) in Methanol (CH₃OH)
2. Sodium Borohydride (NaBH₄) in Ethanol (EtOH)
3. Borane (BH₃) in Tetrahydrofuran (THF)
4. Pyridinium Chlorochromate (PCC) in Dichloromethane (CH₂Cl₂)
5. Phenyllithium (PhLi) in Diethyl Ether (Et₂O)
6. Ozone (O₃) in Dichloromethane (CH₂Cl₂)
7. Phosphoric Acid (H₃PO₄) and Heat
8. Hydrogen Peroxide (H₂O₂) with Sodium Hydroxide (NaOH)
**Diagram Explanation:**
The diagram shows a chemical transformation from cyclohexene (left) to cyclohexanone (right). The task is to select appropriate reagents from the list to accomplish this transformation. Cyclohexene is a simple alkene, and cyclohexanone is a ketone. The reaction involves the oxidation of the alkene to form the ketone.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F8a98c306-c589-4f52-9305-c3af127d02d9%2Fec196031-039b-4989-a850-eea42bc70da0%2F6arqa8_processed.png&w=3840&q=75)
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