Upper jaws DNAwraps around the A subunits in a right-handed direction. DNA binds to Upper jaws clamp onto DNA. the lower jaws. DNA held in lower jaws is cut. DNA held in upper jaws is released and passes downward through the opening in the cut DNA. This process Lower jaws DNA | A subunits B subunits uses 2 ATP molecules. (a) Molecular mechanism of DNA gyrase function Cut DNA is ligated back together and the DNA is released from DNA gyrase. Circular DNA molecule DNA gyrase 2 ATP 2 negative supercoils (b) Overview of DNA gyrase function FIGURE 10.6 The action of DNA gyrase. (a) DNA gyrase, also known as topoisomerase II, is composed of two A and two B subunits. The lower jaws and then the upper jaws bind to two regions of DNA. The lower region is wrapped around the A subunits, which then cleave this DNA. The unbroken segment of DNA is released from the upper jaws and passes through the break. The break is repaired. ONLINE ANIMATION The B subunits capture the energy from the hydrolysis of 2 ATP molecules to catalyze this process. (b) The result is that two negative turns have been introduced into the DNA molecule.

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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In your own words, describe the step that requires the use of ATP.

Upper jaws
DNAwraps around
the A subunits in a
right-handed direction.
DNA binds to
Upper jaws
clamp onto DNA.
the lower jaws.
DNA held in lower jaws
is cut. DNA held in upper
jaws is released and passes
downward through the opening
in the cut DNA. This process
Lower jaws
DNA
| A subunits
B subunits
uses 2 ATP molecules.
(a) Molecular mechanism of DNA gyrase function
Cut DNA is ligated back
together and the DNA is
released from DNA gyrase.
Circular
DNA
molecule
DNA gyrase
2 ATP
2 negative
supercoils
(b) Overview of DNA gyrase function
FIGURE 10.6 The action of DNA gyrase. (a) DNA gyrase, also known as topoisomerase II, is composed of two A and two B
subunits. The lower jaws and then the upper jaws bind to two regions of DNA. The lower region is wrapped around the A subunits, which
then cleave this DNA. The unbroken segment of DNA is released from the upper jaws and passes through the break. The break is repaired.
ONLINE
ANIMATION
The B subunits capture the energy from the hydrolysis of 2 ATP molecules to catalyze this process. (b) The result is that two negative
turns have been introduced into the DNA molecule.
Transcribed Image Text:Upper jaws DNAwraps around the A subunits in a right-handed direction. DNA binds to Upper jaws clamp onto DNA. the lower jaws. DNA held in lower jaws is cut. DNA held in upper jaws is released and passes downward through the opening in the cut DNA. This process Lower jaws DNA | A subunits B subunits uses 2 ATP molecules. (a) Molecular mechanism of DNA gyrase function Cut DNA is ligated back together and the DNA is released from DNA gyrase. Circular DNA molecule DNA gyrase 2 ATP 2 negative supercoils (b) Overview of DNA gyrase function FIGURE 10.6 The action of DNA gyrase. (a) DNA gyrase, also known as topoisomerase II, is composed of two A and two B subunits. The lower jaws and then the upper jaws bind to two regions of DNA. The lower region is wrapped around the A subunits, which then cleave this DNA. The unbroken segment of DNA is released from the upper jaws and passes through the break. The break is repaired. ONLINE ANIMATION The B subunits capture the energy from the hydrolysis of 2 ATP molecules to catalyze this process. (b) The result is that two negative turns have been introduced into the DNA molecule.
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