under theromodynamic base conditions, the below system gives alkylation at the less substituted alpha carbon. This is because HA is constrained so that it possesses no orbital with the carbonyl pi system of the carbonyl, thus the corresponding conjugate base cannot into the carbonyl and is not stabilized, thus HA is not acidic. H Ме H. Mel H. НА НА

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Chapter1: Chemical Foundations
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under theromodynamic base conditions, the below system gives alkylation at the less substituted
alpha carbon. This is because HA is constrained so that it possesses no orbital
with the carbonyl pi system of the carbonyl, thus the corresponding conjugate base cannot
into the carbonyl and is not stabilized, thus HA is not acidic.
H
Ме
NaOEt
H.
Mel
НА
НА
Transcribed Image Text:under theromodynamic base conditions, the below system gives alkylation at the less substituted alpha carbon. This is because HA is constrained so that it possesses no orbital with the carbonyl pi system of the carbonyl, thus the corresponding conjugate base cannot into the carbonyl and is not stabilized, thus HA is not acidic. H Ме NaOEt H. Mel НА НА
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