Trypsin treatment Asn-Thr-Trp-Met-lle-Lys Gly-Tyr-Met-Gln-Phe Val-Leu-Gly-Met–Ser-Arg Cyanogen bromide treatment Gln-Phe Val-Leu-Gly-Met Ile-Lys Gly-Tyr-Met Ser-Arg-Asn-Thr-Trp-Met

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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A sample of an unknown peptide was divided
into two aliquots. One aliquot was treated with trypsin; the other
was treated with cyanogen bromide. Given the following sequences
(N-terminal to C-terminal) of the resulting fragments, deduce the
sequence of the original peptide.

Trypsin treatment
Asn-Thr-Trp-Met-lle-Lys
Gly-Tyr-Met-Gln-Phe
Val-Leu-Gly-Met–Ser-Arg
Cyanogen bromide treatment
Gln-Phe
Val-Leu-Gly-Met
Ile-Lys Gly-Tyr-Met
Ser-Arg-Asn-Thr-Trp-Met
Transcribed Image Text:Trypsin treatment Asn-Thr-Trp-Met-lle-Lys Gly-Tyr-Met-Gln-Phe Val-Leu-Gly-Met–Ser-Arg Cyanogen bromide treatment Gln-Phe Val-Leu-Gly-Met Ile-Lys Gly-Tyr-Met Ser-Arg-Asn-Thr-Trp-Met
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