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Tris(hydroxymethyl)aminomethane [(HOCH2)3CNH2, MW = 121.14] is commonly referred to as Tris or THAM.  THAM is a weak base frequently used to prepare buffers in biochemistry.  Its Kb is 1.2 x 10−6. What weight of THAM must be taken with 100. mL of 0.50 M HCl to prepare 1 L of a pH 7.4 buffer?  (Assume no volume change.)

Tris(hydroxymethyl)aminomethane [(HOCH2)3CNH2, MW = 121.14] is commonly referred to as Tris or THAM.  THAM is a weak base frequently used to prepare buffers in biochemistry.  Its Kb is 1.2 x 10−6. What weight of THAM must be taken with 100. mL of 0.50 M HCl to prepare 1 L of a pH 7.4 buffer?  (Assume no volume change.)

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
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Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Tris(hydroxymethyl)aminomethane [(HOCH2)3CNH2, MW = 121.14] is commonly referred to as Tris or THAM.  THAM is a weak base frequently used to prepare buffers in biochemistry.  Its Kb is 1.2 x 10−6. What weight of THAM must be taken with 100. mL of 0.50 M HCl to prepare 1 L of a pH 7.4 buffer?  (Assume no volume change.)

The image depicts a chemical equilibrium between THAM (B) and its protonated form (BH⁺) in an aqueous solution. The equilibrium is represented by a bidirectional arrow, conveying that the reaction can proceed in both directions. - On the left side of the equation, the chemical structure labeled THAM (B) is shown. This molecule features three hydroxyl groups (OH) and one amino group (NH₂) connected to a carbon backbone. - The reaction involves water (H₂O). - On the right side, the protonated form of THAM (BH⁺) is displayed. The structural difference is the conversion of the NH₂ group to NH₃⁺, indicating the acceptance of a proton (H⁺). This reaction is significant in demonstrating acid-base equilibrium in chemical processes. The depiction offers insight into how THAM can act as a buffer in biological and chemical systems by maintaining pH levels.
Transcribed Image Text:The image depicts a chemical equilibrium between THAM (B) and its protonated form (BH⁺) in an aqueous solution. The equilibrium is represented by a bidirectional arrow, conveying that the reaction can proceed in both directions. - On the left side of the equation, the chemical structure labeled THAM (B) is shown. This molecule features three hydroxyl groups (OH) and one amino group (NH₂) connected to a carbon backbone. - The reaction involves water (H₂O). - On the right side, the protonated form of THAM (BH⁺) is displayed. The structural difference is the conversion of the NH₂ group to NH₃⁺, indicating the acceptance of a proton (H⁺). This reaction is significant in demonstrating acid-base equilibrium in chemical processes. The depiction offers insight into how THAM can act as a buffer in biological and chemical systems by maintaining pH levels.
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