Travoprost is a drug used to treat the build-up of pressure in the eye. It is administered as eye drops. HO CF3 Travoprost (pressure inside the eye, including glaucoma) a) Redraw the structure and incorporate suitable modifications or functional group(s) to: i) increase the polarity of the molecule ii) increase the lipophilicity of the molecule In each case, briefly explain what change(s) you have incorporated and the rationale behind your structural modification. b) Redraw the structure and identify 5 sites that could be targeted by metabolic enzymes, such as cytochrome P450s or transferases. Show two examples of structures arising from potential metabolic activity, using an enzyme or enzymes of Your choice,

Travoprost is a drug used to treat the build-up of pressure in the eye. It is administered as eye drops. HO CF3 Travoprost (pressure inside the eye, including glaucoma) a) Redraw the structure and incorporate suitable modifications or functional group(s) to: i) increase the polarity of the molecule ii) increase the lipophilicity of the molecule In each case, briefly explain what change(s) you have incorporated and the rationale behind your structural modification. b) Redraw the structure and identify 5 sites that could be targeted by metabolic enzymes, such as cytochrome P450s or transferases. Show two examples of structures arising from potential metabolic activity, using an enzyme or enzymes of Your choice,

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

See similar textbooks

Related questions

Q: peptides 1 A peptide bond is classified as a(n) bond. Select an answer and submit. For keyboard…

A: Explanation to the correct answer is given below.

Q: The membrane lipid shown is a phospholipid one saturated fatty acid molecule. - It is derived from a…

A: Polymers of fatty acids having a long, non-polar hydrocarbon chain and a tiny, oxygen-containing…

Q: Draw two different possible hydrogen-bonding interactions between twomolecules of formamide…

A: Hydrogen bonds are the weaker bond than the covalent bond. These bonds are established between two…

Q: None

A: Here's why:Client - centered therapy (c) :Carl Rogers developed client-centered therapy, also known…

Q: Hexadecyltrimethylammonium chloride, CH3(CH2)15N(CH3)+3 Cl-, is one of a class of cationic…

A: The part of a system in which there is an electronegativity difference between the atoms is called…

Q: to which class of lipid does the following molecule belong? a) triacylglycerol b) steroid c)…

A: Lipids are molecules that contain hydrocarbons and make up the building blocks of the structure and…

Q: What is the functional group of each ring in Erythromycin?

A: FUNCTIONAL GROUPS IN Erythromycin:- OH- alcohol RCOOR' - Ester RCOR' - Ketone ROR' - ether R2NR'…

Q: What type of nitrogen functional group is shown in this picture? NH₂ A) primary amine B) secondary…

A: Formula of ammonia is ----- NH3 When one hydrogen atom of ammonia (NH3) is replaced by one alkyl…

Q: 1. Examine the following 12 organic compounds and answer the following questions. Answer by writing…

A: H-bond donors: The donor in a H-bond is usually a strongly electronegative atom such as N, O, or F…

Q: Give the Structures that 3° amine a 1 halide only one chiral Carbon with formula CHIH14 Br No and…

A: We can define the structure with the desired criteria by closely observing the given molecular…

Q: A certain lipid has the structure shown below (R1 and R2 are fatty acyl chains). Could a sample of…

A: Lipid are the molecules that contain hydrocarbons and which are the building blocks of the structure…

Q: In which solvents or solutions will a lipid be soluble: (a) CH 2Cl 2; (b) 5% aqueous NaCl solution;…

A: Given: (a) CH2Cl2; (b) 5% aqueous NaCl solution; (c) CH3CH2CH2CH2CH3? To find: find…

Q: The structure of the amino acid alanine (CH3CHNH2COOHCH3CHNH2COOH) contains a hydrogen atom, a…

Q: List, in order from strongest to weakest, all of the types of attractive non-covalent forces that…

A: There are various types of non-covalent interaction present among the amino acid side chain which is…

Q: Complete the road map for the synthesis of a triglyceride of Lauric acid. ACI a) NaOH b) H3O+ ^g a)…

A: For the synthesis of triglycerides of lauric acid 3-chloroprop-1-ene reacts with sodium alkoxide of…

Q: A certain phospholipid molecule contains two fatty acid chains of eight carbon atoms each having no…

A: Structure of the phospholipid molecule: X group in the structure is

Q: What type of lipid molecule is shown below? но fatty acid wax steroid phospholipid O triglyceride

Q: What is the master formulae of the nicotine chewing gum? Please answer at your own easy words.

A: Nicotine chewing gum is a medicine which helps people to quit smoking.

Q: A triacylglycerol is made up of a glycerol molecule and three fatty acid chains. During hydrolysis,…

Q: Explain why cholesterol, a compound with molecular formula C 27H 46O and one OH group, is soluble in…

A: Cholesterol is soluble in CCl4 but insoluble in water.

Concept explainers

Micelles and Biological Membrane

Micelles are the type of lipid molecules that organize themselves in spherical shape in aqueous solutions. The production of the micelle is a reply to the amphipathic behavior of fatty acids. It means that they consist of both hydrophobic regions and hydrophilic regions. In micelles, polar head groups (hydrophilic groups) produce an outer layer associated with water whereas nonpolar tails (hydrophobic groups) are organized in the interior.

Question

Travoprost is a drug used to treat the build-up of pressure in the eye. It is
administered as eye drops.
HO
CF3
ÕH
Travoprost (pressure inside the eye, including glaucoma)
a) Redraw the structure and incorporate suitable modifications or functional group(s)
to:
i) increase the polarity of the molecule
ii) increase the lipophilicity of the molecule
In each case, briefly explain what change(s) you have incorporated and the rationale
behind your structural modification.
b) Redraw the structure and identify 5 sites that could be targeted by metabolic
enzymes, such as cytochrome P450s or transferases. Show two examples of
structures arising from potential metabolic activity, using an enzyme or enzymes of
your choice.

Expert Solution

This question has been solved!

Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.

SEE SOLUTION Check out a sample Q&A here

Step 1

VIEW

Step 2

VIEW

Step by step

Solved in 2 steps with 3 images

SEE SOLUTION Check out a sample Q&A here

Knowledge Booster

Learn more about

Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.

Similar questions

ČH2OH СНО СНО CHO CHO HO -H- H OH но H OH HO+H H FOH H OH H OH HO H OH H- H- Но HO- H- -HO- Но HO- Но ČH2OH CH2OH ČH,OH ČH2OH а. b. С. d. 15. Which of the following statements describes lipids? Lipids all have the steroid backbone. The body stores excess calories as lipids. Lipids are insoluble in water, but soluble in nonpolar solvents. Lipids are soluble in water, but insoluble in nonpolar solvents. Lipids are insoluble in all solvents. a. b. С. d. е.
A simple triacylglycerol is one that: a) Upon hydrolysis produces glycerol and three different fatty acids. b) Upon hydrolysis produces glycerol and at least two different fatty acids. c) Upon saponification gives glycerol and three fatty acid salts. d) Upon saponification gives three esters. e) Upon hydrolysis produces glycerol and three mol of a fatty acid.
Please help answer the question on natural polymers proteins 1) sketch the two amino acids. Contrast the polarity of the side chains Dna 1) what are the predominant groups in dna 2) the covalent linkage between nucleotides is called a phosphodiester bond. Sketch the linkage
es/74576/quizzes/126123/take U secondary O primary O tertiary O quaternary Question 22 Classify the compound below. H H-c-o-c-(CH216CH3 II H-c-o-c-(CH2)14CH3 H-c-o-c-(CH2),CH=CH(CH2),CH3 O fatty acid O monounsaturated triglyceride O saturated triglyceride O wax ester Question 23 Classify the functional group and amino acid in the statements below. но MacBook Pro
View Policies 11 Current Attempt in Progress The compound 8-chloroadenosine interferes with several cellular processes and inhibits the proliferation of cancer cells. Draw the structure of this compound
Please solve both
Describe the structure of a lipid bilayer. Drag the terms on the left to the appropriate blanks on the right to complete the sentences. Reset Help tails The lipid bilayer consists of rows of with the three hydrophobic forming the center of the bilayer. The hydrophilic polar are situated along the outside of the bilayer. This bilayer creates a separation between the contents of a cell and its surroundings. fatty acids steroids nonpolar phospholipids two heads
How many banos do primary amines have in the region of 3200-3400 cm in the inirared2 a) zero b) one d) three Which one of these could be a monomer for a condensation polymer? H₂NCH₂ b) FC-CF₂ e) H/NCH/CH₂OH d) HOCH Amines with more than 6 carbons are soluble in: b) aqueous NaHCO d) water a) aqueous HCI c) aqueous NaOH Which of the following would give a positive iodoform test? a) benzophenone c) 3-pentanone b) acetone d) cyclopentanone
4. Which acid and alcohol must be reacted to generate the indicated esters? (a) (b) (c) ов ↑ (d) OH
why do amides boil at higher temperatures than hydrocarbons or ethers of similar molecular weights
Can glycerol be used as a solvent for sodium chloride. If it can, what would be the byproduct of this?
Choose from: A = intermolecular H-bonding B = London dispersion forces C = intramolecular H-bonding D = dipole-dipole interaction E = ion-dipole interaction Benzene’s solubility in water is very low (0.08 g/100 mL) but that of toluene is even lower (0.06 g/100mL). This is due to a greater extent of All carbonyl compounds with 5 carbon atoms or less are hydrophilic due to ____.