Time to recurrence of brain metastasis was evaluated on 48 patients. 23 of the patients received treatment with radiotherapy alone and 25 patients received surgery to remove the tumor followed by radiotherapy. You are given the SAS output below to evaluate the 2 different treatments. The variable combo = 1 if the patient received both surgery and radiotherapy and combo = 0 if the patient received radiotherapy alone. ( See images uploaded for SAS output and survival curves)    a. Which treatment to do you prefer? Use an appropriate hypothesis test (following all of the steps) to support your decision. b. Suppose you are told that the 95% confidence interval for the HR comparing treatment with radiotherapy + surgery to treatment with radiotherapy alone is (0.54, 1.32). Do you think this is reasonable? Why or why not?

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Time to recurrence of brain metastasis was evaluated on 48 patients. 23 of the patients received treatment with radiotherapy alone and 25 patients received surgery to remove the tumor followed by radiotherapy. You are given the SAS output below to evaluate the 2 different treatments. The variable combo = 1 if the patient received both surgery and
radiotherapy and combo = 0 if the patient received radiotherapy alone.

( See images uploaded for SAS output and survival curves) 

 

a. Which treatment to do you prefer? Use an appropriate hypothesis test (following all of the steps) to support your decision.
b. Suppose you are told that the 95% confidence interval for the HR comparing treatment with radiotherapy + surgery to treatment with radiotherapy alone is (0.54, 1.32). Do you think this is reasonable? Why or why not?

 

Test of Equality over Strata
Pr >
Test
Chi-Square
DF
Chi-Square
Log-Rank
15.7833
1
<.0001
Wilcoxon
15.6843
1
<.0001
-2Log(LR)
9.1845
1
0.0024
Transcribed Image Text:Test of Equality over Strata Pr > Test Chi-Square DF Chi-Square Log-Rank 15.7833 1 <.0001 Wilcoxon 15.6843 1 <.0001 -2Log(LR) 9.1845 1 0.0024
Product-Limit Survival Estimates
1.0
+ Censored
0.8
0.6
++H +
0.4
0.2
0.0
50
100
150
200
time
combo
1
Survival Probability
Transcribed Image Text:Product-Limit Survival Estimates 1.0 + Censored 0.8 0.6 ++H + 0.4 0.2 0.0 50 100 150 200 time combo 1 Survival Probability
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