Thiamin diphosphate (TPP), a derivative of vitamin B1 required for glucose metabolism, is a weak acid that can be deprotonated by a base. Assign formal charges (FCs), if any, to the appropriate atoms in TPP deprotonated product and determine an overall charge of the species. Do not use any alternative or resonance structures for FC determination. Hint: add missing lone pair(s) to each atom first. H 3 S5 N- %3D H,N PZ Base H,N P 10 I010 1N 1N 3: Thiamin diphosphate (TPP) deprotonated form of TPP

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Thiamin diphosphate (TPP), a derivative of vitamin B, required for glucose metabolism, is a weak
acid that can be deprotonated by a base. Assign formal charges (FCs), if any, to the appropriate
atoms in TPP deprotonated product and determine an overall charge of the species. Do not use any
alternative or resonance structures for FC determination.
Hint: add missing lone pair(s) to each atom first.
H.
4
3 S5
N-
24
3 S5
N-
2
H2N
PZ
Base
H,N
10
PZ
P10
O.
1N
9.
1N
9.
Thiamin diphosphate (TPP)
deprotonated form of TPP
Transcribed Image Text:Thiamin diphosphate (TPP), a derivative of vitamin B, required for glucose metabolism, is a weak acid that can be deprotonated by a base. Assign formal charges (FCs), if any, to the appropriate atoms in TPP deprotonated product and determine an overall charge of the species. Do not use any alternative or resonance structures for FC determination. Hint: add missing lone pair(s) to each atom first. H. 4 3 S5 N- 24 3 S5 N- 2 H2N PZ Base H,N 10 PZ P10 O. 1N 9. 1N 9. Thiamin diphosphate (TPP) deprotonated form of TPP
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