There is a medical condition called Syndrome of Inappropriate Anti-Diuretic Hormone (SIADH) secretion, which can occur as a result of head trauma. Patients with this condition retain water and present with a volume imbalance. A) Name the type of volume imbalance and accompanying direction of changes in ICF and ECF volumes and osmolality.

Biochemistry
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Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
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1. There is a medical condition called Syndrome of Inappropriate Anti-Diuretic
Hormone (SIADH) secretion, which can occur as a result of head trauma. Patients with
this condition retain water and present with a volume imbalance.

A) Name the type of volume imbalance and accompanying direction of changes in ICF and ECF volumes and
osmolality. 

B) Calculate the changes in osmolality and volumes of extracellular
and intracellular fluid compartments if 3 liters of water are retained by a patient with
SIADH. You can assume that the patient’s initial volumes were ECF=14 L, ICF=28 L. And
his initial body osmolality = 290 mOsM. Remember that the total solute in the ICF
compartment is kept in place by the cell membrane barrier.

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