There are two variants of the enhancer sequence found in people. One has the sequence CACTAAAG, and this sequence is the binding site for a transcription factor. It is associated with dark hair. The other form has the sequence CGCTAAG at the same binding site for the same transcription factor. It is associated with blonde hair How can this small sequence difference be responsible for the observation that they lead to different rates of transcription and expression of the gene targeted by this enhancer.

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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3) There are two variants of the enhancer sequence found in people. One has the sequence CACTAAAG, and this
sequence is the binding site for a transcription factor. It is associated with dark hair. The other form has the
sequence CGCTAAG at the same binding site for the same transcription factor. It is associated with blonde hair.
How can this small sequence difference be responsible for the observation that they lead to different rates of
transcription and expression of the gene targeted by this enhancer.
Transcribed Image Text:3) There are two variants of the enhancer sequence found in people. One has the sequence CACTAAAG, and this sequence is the binding site for a transcription factor. It is associated with dark hair. The other form has the sequence CGCTAAG at the same binding site for the same transcription factor. It is associated with blonde hair. How can this small sequence difference be responsible for the observation that they lead to different rates of transcription and expression of the gene targeted by this enhancer.
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