The residential drinking water in a small town with a population of 50,000 has been detected to contains 0.5 ppb tetrachloroethylene. There is also a waste incineration plant in the town that emits 0.001 ppb dioxin. Long-term health monitoring of the town yielded the following data:   With Disease  Without Disease Exposed 72 185 Not exposed 34 560 Show how to calculate the CDI values for the 2 contaminants: (CDI_TCE = 5.86x10-6 mg/kg/d, CDI_Dioxin = 1.17x10-8 mg/kg/d)

Structural Analysis
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The residential drinking water in a small town with a population of 50,000 has been detected to contains 0.5 ppb tetrachloroethylene. There is also a waste incineration plant in the town that emits 0.001 ppb dioxin. Long-term health monitoring of the town yielded the following data:

  With Disease  Without Disease
Exposed 72 185
Not exposed 34 560
  1. Show how to calculate the CDI values for the 2 contaminants: (CDI_TCE = 5.86x10-6 mg/kg/d, CDI_Dioxin = 1.17x10-8 mg/kg/d)
  2. Show how to calculate the number of cancers caused: 0.01 cases caused by TCE and 91 cases caused by Dioxin 
TABLE 9
Toxicity Data for Selected Potential Carcinogens
Potency Factor
Oral Route
Chemical
Category
(mg/kg-day)-1
Arsenic
A
1.75
Benzene
A
2.9 × 10-2
Benzol(a)pyrene
Cadmium
B2
11.5
В1
-
Carbon tetrachloride
B2
0.13
Chloroform
B2
6.1 × 10-3
Chromium VI
A
-
DDT
B2
0.34
1,1-Dichloroethylene
Dieldrin
C
0.58
B2
30
Heptachlor
Hexachloroethane
B2
3.4
1.4 × 10-2
7.5 × 10-3
Methylene chloride
Nickel and compounds
Polychlorinated biphenyls (PCBS)
2,3,7,8-TCDD (dioxin)
Tetrachloroethylene
1,1,1-Trichloroethane (1,1,1-TCA)
Trichloroethylene (TCE)
Vinyl chloride
B2
A
B2
7.7
1.56 X 105
5.1 × 10-2
B2
B2
D
-
B2
1.1 × 10-2
A
2.3
Source: U.S. EPA, www.epa.gov/iris.
Transcribed Image Text:TABLE 9 Toxicity Data for Selected Potential Carcinogens Potency Factor Oral Route Chemical Category (mg/kg-day)-1 Arsenic A 1.75 Benzene A 2.9 × 10-2 Benzol(a)pyrene Cadmium B2 11.5 В1 - Carbon tetrachloride B2 0.13 Chloroform B2 6.1 × 10-3 Chromium VI A - DDT B2 0.34 1,1-Dichloroethylene Dieldrin C 0.58 B2 30 Heptachlor Hexachloroethane B2 3.4 1.4 × 10-2 7.5 × 10-3 Methylene chloride Nickel and compounds Polychlorinated biphenyls (PCBS) 2,3,7,8-TCDD (dioxin) Tetrachloroethylene 1,1,1-Trichloroethane (1,1,1-TCA) Trichloroethylene (TCE) Vinyl chloride B2 A B2 7.7 1.56 X 105 5.1 × 10-2 B2 B2 D - B2 1.1 × 10-2 A 2.3 Source: U.S. EPA, www.epa.gov/iris.
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